3β-(Benzoyloxy)-8β-hydroxy-4,4-dimethyl-7-oxo-5α-cholestane-14α-carbonitrile

Base Information

• Chemical Name: 3β-(Benzoyloxy)-8β-hydroxy-4,4-dimethyl-7-oxo-5α-cholestane-14α-carbonitrile
• CAS No.: 141273-70-3
• Molecular Formula: C₃₇H₅₃NO₄
• Molecular Weight: 575.832
• Mol file: 141273-70-3.mol

Synonyms:3β-(Benzoyloxy)-8β-hydroxy-4,4-dimethyl-7-oxo-5α-cholestane-14α-carbonitrile

Chemical Property of 3β-(Benzoyloxy)-8β-hydroxy-4,4-dimethyl-7-oxo-5α-cholestane-14α-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3β-(Benzoyloxy)-8β-hydroxy-4,4-dimethyl-7-oxo-5α-cholestane-14α-carbonitrile

There total 7 articles about 3β-(Benzoyloxy)-8β-hydroxy-4,4-dimethyl-7-oxo-5α-cholestane-14α-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3β-(Benzoyloxy)-8β-hydroperoxy-4,4-dimethyl-7-oxo-5α-cholestane-14α-carbonitrile (141273-69-0) → 3β-(Benzoyloxy)-8β-hydroxy-4,4-dimethyl-7-oxo-5α-cholestane-14α-carbonitrile (141273-70-3)

Guidance literature:

With acetic acid; zinc; In dichloromethane; for 24h; Yield given; Ambient temperature;

DOI:10.1021/jo00038a024

Reference yield:

4,4-dimethyl-5α-cholest-7-en-3β-ol (6384-28-7) → 3β-(Benzoyloxy)-8β-hydroxy-4,4-dimethyl-7-oxo-5α-cholestane-14α-carbonitrile (141273-70-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 93 percent / pyridine / 18 h / Ambient temperature

2: 1) SeO₂, HOAc, 2) CrO₃, H₂O / 1) H₂O, toluene, r.t., 18 h, 2) 3 h

3: Zn, HOAc / 3 h / Heating

4: toluene / 0.5 h / 0 °C

5: O₂ / CH₂Cl₂

6: Zn, HOAc / CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; chromium(VI) oxide; selenium(IV) oxide; water; oxygen; acetic acid; zinc; In dichloromethane; toluene;

DOI:10.1021/jo00038a024

Reference yield:

3β-(Benzoyloxy)-4,4-dimethyl-5α-cholest-8(14)-en-7-one (2548-14-3) → 3β-(Benzoyloxy)-8β-hydroxy-4,4-dimethyl-7-oxo-5α-cholestane-14α-carbonitrile (141273-70-3)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 0.5 h / 0 °C

2: O₂ / CH₂Cl₂

3: Zn, HOAc / CH₂Cl₂ / 24 h / Ambient temperature

With oxygen; acetic acid; zinc; In dichloromethane; toluene;

DOI:10.1021/jo00038a024

upstream raw materials:

3β-(Benzoyloxy)-8β-hydroperoxy-4,4-dimethyl-7-oxo-5α-cholestane-14α-carbonitrile

4,4-dimethyl-5α-cholest-7-en-3β-ol

3β-(Benzoyloxy)-4,4-dimethyl-5α-cholest-8(14)-en-7-one

3β-(Benzoyloxy)-4,4-dimethyl-5α-cholest-7-ene

Downstream raw materials:

3β-(Benzoyloxy)-4,4-dimethyl-7-oxo-5α-cholest-8-ene-14α-carbonitrile