5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(5-(morpholinomethyl)thiophen-2-yl)isoxazole-3-carboxamide

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Chemical Name:5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(5-(morpholinomethyl)thiophen-2-yl)isoxazole-3-carboxamide
CAS No.:1330736-04-3
Molecular Formula:C₂₄H₂₉N₃O₅S
Molecular Weight:471.577
Hs Code.:

Synonyms:5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(5-(morpholinomethyl)thiophen-2-yl)isoxazole-3-carboxamide

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Chemical Property of 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(5-(morpholinomethyl)thiophen-2-yl)isoxazole-3-carboxamide

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Technology Process of 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(5-(morpholinomethyl)thiophen-2-yl)isoxazole-3-carboxamide

There total 4 articles about 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(5-(morpholinomethyl)thiophen-2-yl)isoxazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1330736-08-7
5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(5-(morpholinomethyl)thiophen-2-yl)isoxazole-3-carboxamide

: 1330736-04-3
5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(5-(morpholinomethyl)thiophen-2-yl)isoxazole-3-carboxamide

Guidance literature:: 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(5-(morpholinomethyl)thiophen-2-yl)isoxazole-3-carboxamide; With boron trichloride; In dichloromethane; at 0 - 20 ℃; for 0.166667h;

With methanol; In dichloromethane;

Reference yield:

: (5-formylthiophen-2-yl)boronic acid

: 1330736-04-3
5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(5-(morpholinomethyl)thiophen-2-yl)isoxazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 0.17 h

1.2: 2 - 3 h / Reflux

2.1: sodium cyanoborohydride / dichloromethane / 1 h

2.2: 20 °C

3.1: boron trichloride / dichloromethane / 0.17 h / 0 - 20 °C

With boron trichloride; sodium cyanoborohydride; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 747414-22-8
5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-iodoisoxazole-3-carboxylic acid ethylamide

: 1330736-04-3
5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(5-(morpholinomethyl)thiophen-2-yl)isoxazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 0.17 h

1.2: 2 - 3 h / Reflux

2.1: sodium cyanoborohydride / dichloromethane / 1 h

2.2: 20 °C

3.1: boron trichloride / dichloromethane / 0.17 h / 0 - 20 °C

With boron trichloride; sodium cyanoborohydride; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;