3-[2-((S)-2-Diethylaminomethyl-pyrrolidin-1-yl)-2-oxo-ethyl]-6,6-dimethyl-5-oxo-heptanoic acid

Base Information

• Chemical Name: 3-[2-((S)-2-Diethylaminomethyl-pyrrolidin-1-yl)-2-oxo-ethyl]-6,6-dimethyl-5-oxo-heptanoic acid
• CAS No.: 185421-00-5
• Molecular Formula: C₂₀H₃₆N₂O₄
• Molecular Weight: 368.517
• Mol file: 185421-00-5.mol

Synonyms:3-[2-((S)-2-Diethylaminomethyl-pyrrolidin-1-yl)-2-oxo-ethyl]-6,6-dimethyl-5-oxo-heptanoic acid

Chemical Property of 3-[2-((S)-2-Diethylaminomethyl-pyrrolidin-1-yl)-2-oxo-ethyl]-6,6-dimethyl-5-oxo-heptanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-((S)-2-Diethylaminomethyl-pyrrolidin-1-yl)-2-oxo-ethyl]-6,6-dimethyl-5-oxo-heptanoic acid

There total 1 articles about 3-[2-((S)-2-Diethylaminomethyl-pyrrolidin-1-yl)-2-oxo-ethyl]-6,6-dimethyl-5-oxo-heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl glutaconate (5164-76-1) → 3-[2-((S)-2-Diethylaminomethyl-pyrrolidin-1-yl)-2-oxo-ethyl]-6,6-dimethyl-5-oxo-heptanoic acid (185421-00-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 57 percent / NaOMe / methanol / 33 h / Ambient temperature

2: conc. HCl / 8 h / Heating

3: acetyl chloride / 3 h / Heating

4: toluene / 48 h / Ambient temperature

With hydrogenchloride; sodium methylate; acetyl chloride; In methanol; toluene;

DOI:10.1016/0040-4020(96)00863-0

Reference yield:

diazodiphenylmethane (908093-98-1) + 3-[2-((S)-2-Diethylaminomethyl-pyrrolidin-1-yl)-2-oxo-ethyl]-6,6-dimethyl-5-oxo-heptanoic acid (185421-00-5) → 3-[2-((S)-2-Diethylaminomethyl-pyrrolidin-1-yl)-2-oxo-ethyl]-6,6-dimethyl-5-oxo-heptanoic acid benzhydryl ester

Guidance literature:

In chloroform; toluene; for 24h; Yield given; Heating;

DOI:10.1016/0040-4020(96)00863-0

upstream raw materials:

dimethyl glutaconate