N-(3-bromophenyl)-6-(2-[18F]fluoroethoxy)-7-methoxyquinazolin-4-amine

Base Information

Chemical Name:N-(3-bromophenyl)-6-(2-[18F]fluoroethoxy)-7-methoxyquinazolin-4-amine
CAS No.:1389355-33-2
Molecular Formula:C₁₇H₁₅BrFN₃O₂
Molecular Weight:391.229
Hs Code.:

Synonyms:N-(3-bromophenyl)-6-(2-[18F]fluoroethoxy)-7-methoxyquinazolin-4-amine

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Chemical Property of N-(3-bromophenyl)-6-(2-[18F]fluoroethoxy)-7-methoxyquinazolin-4-amine

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Technology Process of N-(3-bromophenyl)-6-(2-[18F]fluoroethoxy)-7-methoxyquinazolin-4-amine

There total 10 articles about N-(3-bromophenyl)-6-(2-[18F]fluoroethoxy)-7-methoxyquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1389355-33-2
N-(3-bromophenyl)-6-(2-[18F]fluoroethoxy)-7-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / isopropyl alcohol / Reflux

2: water; sodium hydroxide / methanol

3: potassium hydroxide / dimethyl sulfoxide / 0.25 h / 100 °C

With pyridine; water; potassium hydroxide; sodium hydroxide; In methanol; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2012.05.069

Reference yield:

: 113426-12-3
[(18)F]-2-fluoroethyltosylate

: 295330-61-9
4-[(3-bromophenyl)amino]-6-hydroxy-7-methoxyquinazoline

: 1389355-33-2
N-(3-bromophenyl)-6-(2-[18F]fluoroethoxy)-7-methoxyquinazolin-4-amine

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; at 100 ℃; for 0.25h;
DOI:10.1016/j.bmcl.2012.05.069

Reference yield:

: 295330-64-2
4-[(3-bromo-phenyl)amino]-6-methylcarbonyloxy-7-methoxy-quinazoline

: 1389355-33-2
N-(3-bromophenyl)-6-(2-[18F]fluoroethoxy)-7-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / methanol

2: potassium hydroxide / dimethyl sulfoxide / 0.25 h / 100 °C

With water; potassium hydroxide; sodium hydroxide; In methanol; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2012.05.069