2-debenzoyl-2-(3-methoxybenzoyl)-7-triethylsilyl-10-deacetyl-10-(methoxycarbonyl)baccatin III

Base Information

Chemical Name:2-debenzoyl-2-(3-methoxybenzoyl)-7-triethylsilyl-10-deacetyl-10-(methoxycarbonyl)baccatin III
CAS No.:1007094-42-9
Molecular Formula:C₃₈H₅₄O₁₃Si
Molecular Weight:746.924
Hs Code.:

Synonyms:2-debenzoyl-2-(3-methoxybenzoyl)-7-triethylsilyl-10-deacetyl-10-(methoxycarbonyl)baccatin III

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Chemical Property of 2-debenzoyl-2-(3-methoxybenzoyl)-7-triethylsilyl-10-deacetyl-10-(methoxycarbonyl)baccatin III

Chemical Property:

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Technology Process of 2-debenzoyl-2-(3-methoxybenzoyl)-7-triethylsilyl-10-deacetyl-10-(methoxycarbonyl)baccatin III

There total 6 articles about 2-debenzoyl-2-(3-methoxybenzoyl)-7-triethylsilyl-10-deacetyl-10-(methoxycarbonyl)baccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-22-1
methyl chloroformate

: 848251-62-7
C₃₆H₅₂O₁₁Si

: 1007094-42-9
2-debenzoyl-2-(3-methoxybenzoyl)-7-triethylsilyl-10-deacetyl-10-(methoxycarbonyl)baccatin III

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -40 ℃;
DOI:10.1016/j.jfluchem.2008.05.013

Reference yield:

: 32981-86-5,172018-16-5
10-deacetylbaccatin III

: 1007094-42-9
2-debenzoyl-2-(3-methoxybenzoyl)-7-triethylsilyl-10-deacetyl-10-(methoxycarbonyl)baccatin III

Guidance literature:: Multi-step reaction with 6 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / -10 °C

3: diisopropyl-carbodiimide; dmap / dichloromethane

4: pyridine; hydrogen fluoride / acetonitrile

5: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

6: lithium hexamethyldisilazane / tetrahydrofuran

With pyridine; 1H-imidazole; dmap; hydrogen fluoride; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium hexamethyldisilazane; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: 194720-19-9
7,10,13-tris(triethylsilyl)-10-deacetylbaccatin III

: 1007094-42-9
2-debenzoyl-2-(3-methoxybenzoyl)-7-triethylsilyl-10-deacetyl-10-(methoxycarbonyl)baccatin III

Guidance literature:: Multi-step reaction with 5 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / -10 °C

2: diisopropyl-carbodiimide; dmap / dichloromethane

3: pyridine; hydrogen fluoride / acetonitrile

4: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

5: lithium hexamethyldisilazane / tetrahydrofuran

With pyridine; 1H-imidazole; dmap; hydrogen fluoride; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium hexamethyldisilazane; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007