tert-butyl 3-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)-3,4-dimethylpiperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)-3,4-dimethylpiperazine-1-carboxylate
CAS No.:519032-02-1
Molecular Formula:C₂₃H₃₀FN₅O₅
Molecular Weight:475.52
Hs Code.:

Synonyms:tert-butyl 3-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)-3,4-dimethylpiperazine-1-carboxylate

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Chemical Property of tert-butyl 3-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)-3,4-dimethylpiperazine-1-carboxylate

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Technology Process of tert-butyl 3-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)-3,4-dimethylpiperazine-1-carboxylate

There total 10 articles about tert-butyl 3-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)-3,4-dimethylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 518048-20-9
1-benzyl-4-tert-butyl-2-cyano-2-methylpiperazine-1,4-dicarboxylate

: 519032-02-1
tert-butyl 3-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)-3,4-dimethylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: NH₂OH / methanol / 60 °C

2: CHCl₃ / 3 h / Heating

3: xylene / 24 h / Heating

4: 0.37 g / pyridine / 20 °C

5: H₂ / Pd/C / ethyl acetate / 760 Torr

6: NaCNBH₃; NaOAc / methanol; H₂O / 0.5 h / 20 °C

7: methanol / Heating

With pyridine; hydrogen; hydroxylamine; sodium acetate; sodium cyanoborohydride; palladium on activated charcoal; In methanol; chloroform; water; ethyl acetate; xylene;
DOI:10.1021/jm070027u

Reference yield:

: 2-carbamoyl-2-methyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

: 519032-02-1
tert-butyl 3-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)-3,4-dimethylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N; trifluoroacetic anhydride / CH₂Cl₂ / 3.5 h / 20 °C

2: NH₂OH / methanol / 60 °C

3: CHCl₃ / 3 h / Heating

4: xylene / 24 h / Heating

5: 0.37 g / pyridine / 20 °C

6: H₂ / Pd/C / ethyl acetate / 760 Torr

7: NaCNBH₃; NaOAc / methanol; H₂O / 0.5 h / 20 °C

8: methanol / Heating

With pyridine; hydrogen; hydroxylamine; sodium acetate; sodium cyanoborohydride; triethylamine; trifluoroacetic anhydride; palladium on activated charcoal; In methanol; dichloromethane; chloroform; water; ethyl acetate; xylene;
DOI:10.1021/jm070027u

Reference yield:

: 940868-18-8
1-[(benzyloxy)carbonyl]-4-(tert-butoxycarbonyl)-2-methylpiperazine-2-carboxylic acid

: 519032-02-1
tert-butyl 3-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)-3,4-dimethylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: di-tert-butyl dicarbonate; NH₄HCO₃; pyridine / dioxane / 20 h / 20 °C

2: Et₃N; trifluoroacetic anhydride / CH₂Cl₂ / 3.5 h / 20 °C

3: NH₂OH / methanol / 60 °C

4: CHCl₃ / 3 h / Heating

5: xylene / 24 h / Heating

6: 0.37 g / pyridine / 20 °C

7: H₂ / Pd/C / ethyl acetate / 760 Torr

8: NaCNBH₃; NaOAc / methanol; H₂O / 0.5 h / 20 °C

9: methanol / Heating

With pyridine; di-tert-butyl dicarbonate; hydrogen; hydroxylamine; sodium acetate; sodium cyanoborohydride; ammonium bicarbonate; triethylamine; trifluoroacetic anhydride; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; chloroform; water; ethyl acetate; xylene;
DOI:10.1021/jm070027u