Technology Process of tert-butyl 3-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)-3,4-dimethylpiperazine-1-carboxylate
There total 10 articles about tert-butyl 3-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)-3,4-dimethylpiperazine-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: NH2OH / methanol / 60 °C
2: CHCl3 / 3 h / Heating
3: xylene / 24 h / Heating
4: 0.37 g / pyridine / 20 °C
5: H2 / Pd/C / ethyl acetate / 760 Torr
6: NaCNBH3; NaOAc / methanol; H2O / 0.5 h / 20 °C
7: methanol / Heating
With
pyridine; hydrogen; hydroxylamine; sodium acetate; sodium cyanoborohydride;
palladium on activated charcoal;
In
methanol; chloroform; water; ethyl acetate; xylene;
DOI:10.1021/jm070027u
- Guidance literature:
-
Multi-step reaction with 8 steps
1: Et3N; trifluoroacetic anhydride / CH2Cl2 / 3.5 h / 20 °C
2: NH2OH / methanol / 60 °C
3: CHCl3 / 3 h / Heating
4: xylene / 24 h / Heating
5: 0.37 g / pyridine / 20 °C
6: H2 / Pd/C / ethyl acetate / 760 Torr
7: NaCNBH3; NaOAc / methanol; H2O / 0.5 h / 20 °C
8: methanol / Heating
With
pyridine; hydrogen; hydroxylamine; sodium acetate; sodium cyanoborohydride; triethylamine; trifluoroacetic anhydride;
palladium on activated charcoal;
In
methanol; dichloromethane; chloroform; water; ethyl acetate; xylene;
DOI:10.1021/jm070027u
- Guidance literature:
-
Multi-step reaction with 9 steps
1: di-tert-butyl dicarbonate; NH4HCO3; pyridine / dioxane / 20 h / 20 °C
2: Et3N; trifluoroacetic anhydride / CH2Cl2 / 3.5 h / 20 °C
3: NH2OH / methanol / 60 °C
4: CHCl3 / 3 h / Heating
5: xylene / 24 h / Heating
6: 0.37 g / pyridine / 20 °C
7: H2 / Pd/C / ethyl acetate / 760 Torr
8: NaCNBH3; NaOAc / methanol; H2O / 0.5 h / 20 °C
9: methanol / Heating
With
pyridine; di-tert-butyl dicarbonate; hydrogen; hydroxylamine; sodium acetate; sodium cyanoborohydride; ammonium bicarbonate; triethylamine; trifluoroacetic anhydride;
palladium on activated charcoal;
In
1,4-dioxane; methanol; dichloromethane; chloroform; water; ethyl acetate; xylene;
DOI:10.1021/jm070027u