2-Chloro-7-methylquinoxaline

Base Information

• Chemical Name: 2-Chloro-7-methylquinoxaline
• CAS No.: 90272-84-7
• Molecular Formula: C9H7 Cl N2
• Molecular Weight: 178.621
• Hs Code.: 2933998090
• DSSTox Substance ID: DTXSID60343268
• Nikkaji Number: J610.137B
• Wikidata: Q82114535
• Mol file: 90272-84-7.mol

Synonyms:2-Chloro-7-methylquinoxaline;90272-84-7;Quinoxaline,2-chloro-7-methyl-;SCHEMBL559386;2-chloro-7-methyl-quinoxaline;DTXSID60343268;AMY32218;MFCD11846473;AKOS015904798;FS-2865;FT-0770037;J-508994

Chemical Property of 2-Chloro-7-methylquinoxaline

Chemical Property:

• Vapor Pressure: 0.0101mmHg at 25°C
• Refractive Index: 1.643
• Boiling Point: 272.5°C at 760 mmHg
• Flash Point: 144.8°C
• PSA: 25.78000
• Density: 1.292g/cm³
• LogP: 2.59160
• Storage Temp.: 2-8°C
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 178.0297759
• Heavy Atom Count: 12
• Complexity: 163

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-7-methylquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=NC(=CN=C2C=C1)Cl
• Uses: 2-Chloro-7-methylquinoxaline is a useful reactant for the synthesis of pentathiepino-?pyrrolo[1,?2-?a]?pyrazine derivatives and 2-?{4-?[(7-?Chloro-?2-?quinoxalinyl)?oxy]?phenoxy}?propionic acid, an active antitumor agent.

Technology Process of 2-Chloro-7-methylquinoxaline

There total 5 articles about 2-Chloro-7-methylquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methylquinoxalin-2(1H)-one (5762-65-2) → 2-chloro-7-methylquinoxaline (90272-84-7)

Guidance literature:

With phosphorus pentachloride; at 140 - 150 ℃;

Reference yield:

N-(4-methyl-2-nitro-phenyl)-glycine (62573-36-8) → 2-chloro-7-methylquinoxaline (90272-84-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tin; concentrated aqueous HCl

2: POCl₃

With hydrogenchloride; tin; trichlorophosphate;

DOI:10.1039/jr9480001310

Reference yield:

7-methyl-3,4-dihydroquinoxalin-2(1H)-one (66367-14-4) → 2-chloro-7-methylquinoxaline (90272-84-7)

Guidance literature:

Multi-step reaction with 2 steps

1: beim Aufbewahren an der Luft

2: phosphorus pentachloride / 140 - 150 °C

With phosphorus pentachloride;

upstream raw materials:

7-methylquinoxalin-2(1H)-one

7-methyl-3,4-dihydroquinoxalin-2(1H)-one

N-(4-methyl-2-nitro-phenyl)-glycine

4-methyl-1,2-diaminobenzene

Downstream raw materials:

N-(2,4-dimethoxybenzyl)-7-methylquinoxalin-2-amine