C₃₁H₃₈Cl₃N₃O₁₈

Base Information

• Chemical Name: C₃₁H₃₈Cl₃N₃O₁₈
• CAS No.: 1426099-69-5
• Molecular Formula: C₃₁H₃₈Cl₃N₃O₁₈
• Molecular Weight: 847.011
• Mol file: 1426099-69-5.mol

Synonyms:C₃₁H₃₈Cl₃N₃O₁₈

Chemical Property of C₃₁H₃₈Cl₃N₃O₁₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₁H₃₈Cl₃N₃O₁₈

There total 15 articles about C₃₁H₃₈Cl₃N₃O₁₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

C44H48Cl3NO19 (1138124-43-2) → C31H38Cl3N3O18 (1426099-69-5)

Guidance literature:

C₄₄H₄₈Cl₃NO₁₉; With palladium 10% on activated carbon; hydrogen; In methanol; for 0.75h; Inert atmosphere;

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; In dichloromethane; water; for 2h; Further stages;

Reference yield:

C37H40Cl3NO20 → C31H38Cl3N3O18 (1426099-69-5)

Guidance literature:

C₃₇H₄₀Cl₃NO₂₀; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -40 ℃; for 0.0833333h; Inert atmosphere;

With ammonia; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja4000933

Reference yield:

(2R,3S,4R,5R,6S)-2-(acetoxymethyl)-6-(phenylthio)-5-(((2,2,2-trichloroethoxy)carbonyl)amino)tetrahydro-2H-pyran-3,4-diyl diacetate (187022-49-7) → C31H38Cl3N3O18 (1426099-69-5)

Guidance literature:

Multi-step reaction with 8 steps

1.1: Selectfluor / water; acetonitrile / 1 h / 20 °C

2.1: 2,6-di-tert-butyl-pyridine; 1,2-dimethoxy-4-(2-propenyl)benzene; trifluoromethylsulfonic anhydride / dichloromethane / 1.5 h / -78 °C / Inert atmosphere; Molecular sieve

3.1: triethylsilane; trifluorormethanesulfonic acid / dichloromethane / 2.5 h / -78 °C / Molecular sieve; Inert atmosphere

4.1: pyridine / dichloromethane / -40 - 20 °C / Inert atmosphere

5.1: 18-crown-6 ether / toluene / 14 h / 20 °C / Inert atmosphere

6.1: hydrogen; palladium 10% on activated carbon / methanol / 0.75 h / 20 °C

7.1: [bis(acetoxy)iodo]benzene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; dichloromethane / 2 h / 20 °C

8.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.08 h / -40 °C / Inert atmosphere

8.2: 24 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; triethylsilane; 2,6-di-tert-butyl-pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 18-crown-6 ether; trifluorormethanesulfonic acid; trifluoromethylsulfonic anhydride; [bis(acetoxy)iodo]benzene; 1,2-dimethoxy-4-(2-propenyl)benzene; palladium 10% on activated carbon; hydrogen; Selectfluor; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;

DOI:10.1021/ja4000933

upstream raw materials:

4-methoxyphenyl 4,6-O-benzylidene-β-D-galactopyranoside

C₂₇H₂₆O₉

phenyl 3,4,6-tri-O-acetyl-2-deoxy-1-thio-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside S-oxide

(2R,3S,4R,5R,6S)-2-(acetoxymethyl)-6-(phenylthio)-5-(((2,2,2-trichloroethoxy)carbonyl)amino)tetrahydro-2H-pyran-3,4-diyl diacetate