8-Methyl-4-methylsulfanyl-1-phenyl-6-propyl-1,2-dihydro-imidazo[1,5-d][1,2,4]triazine

Base Information

• Chemical Name: 8-Methyl-4-methylsulfanyl-1-phenyl-6-propyl-1,2-dihydro-imidazo[1,5-d][1,2,4]triazine
• CAS No.: 97751-64-9
• Molecular Formula: C₁₆H₂₀N₄S
• Molecular Weight: 300.428

Synonyms:8-Methyl-4-methylsulfanyl-1-phenyl-6-propyl-1,2-dihydro-imidazo[1,5-d][1,2,4]triazine

Chemical Property of 8-Methyl-4-methylsulfanyl-1-phenyl-6-propyl-1,2-dihydro-imidazo[1,5-d][1,2,4]triazine

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Technology Process of 8-Methyl-4-methylsulfanyl-1-phenyl-6-propyl-1,2-dihydro-imidazo[1,5-d][1,2,4]triazine

There total 2 articles about 8-Methyl-4-methylsulfanyl-1-phenyl-6-propyl-1,2-dihydro-imidazo[1,5-d][1,2,4]triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

8-methyl-4-(methylthio)-6-propylimidazo<1,5-d><1,2,4>triazine (69195-49-9) + phenylmagnesium bromide → 8-Methyl-4-methylsulfanyl-1-phenyl-6-propyl-1,2-dihydro-imidazo[1,5-d][1,2,4]triazine (97751-64-9)

Guidance literature:

In tetrahydrofuran; diethyl ether; for 4.5h; Heating;

DOI:10.1021/jm00149a029

Reference yield:

8-methyl-6-propyl-3H-imidazo[1,5-d][1,2,4]triazine-4-thione (68325-00-8) → 8-Methyl-4-methylsulfanyl-1-phenyl-6-propyl-1,2-dihydro-imidazo[1,5-d][1,2,4]triazine (97751-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium hydride / 1.) DMF, 2.) DMF, overnight

2: 54 percent / tetrahydrofuran; diethyl ether / 4.5 h / Heating

With sodium hydride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jm00149a029

Reference yield: 54.0%

8-Methyl-4-methylsulfanyl-1-phenyl-6-propyl-1,2-dihydro-imidazo[1,5-d][1,2,4]triazine (97751-64-9) → 8-Methyl-4-methylsulfanyl-1-phenyl-6-propyl-imidazo[1,5-d][1,2,4]triazine (97751-19-4)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In chloroform; for 2h;

DOI:10.1021/jm00149a029

upstream raw materials:

8-methyl-4-(methylthio)-6-propylimidazo<1,5-d><1,2,4>triazine

8-methyl-6-propyl-3H-imidazo[1,5-d][1,2,4]triazine-4-thione

Downstream raw materials:

8-Methyl-4-methylsulfanyl-1-phenyl-6-propyl-imidazo[1,5-d][1,2,4]triazine

8-methyl-1-phenyl-6-propylimidazo<1,5-d><1,2,4>triazin-4(3H)-one

(8-Methyl-1-phenyl-6-propyl-imidazo[1,5-d][1,2,4]triazin-4-yl)-(1H-pyrazol-3-yl)-amine

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