(E)-N-(4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)-N'-(7-(trifluoromethyl)quinolin-4-yl)carbamimidothioic acid

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Chemical Name:(E)-N-(4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)-N'-(7-(trifluoromethyl)quinolin-4-yl)carbamimidothioic acid
CAS No.:1491007-12-5
Molecular Formula:C₂₂H₁₈F₃N₅O₃S₂
Molecular Weight:521.544
Hs Code.:

Synonyms:(E)-N-(4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)-N'-(7-(trifluoromethyl)quinolin-4-yl)carbamimidothioic acid

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Chemical Property of (E)-N-(4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)-N'-(7-(trifluoromethyl)quinolin-4-yl)carbamimidothioic acid

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Technology Process of (E)-N-(4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)-N'-(7-(trifluoromethyl)quinolin-4-yl)carbamimidothioic acid

There total 2 articles about (E)-N-(4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)-N'-(7-(trifluoromethyl)quinolin-4-yl)carbamimidothioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 4-isothiocyanato-7-(triflouromethyl)quinoline

: 127-69-5
sulfisoxazole

: 1491007-12-5
(E)-N-(4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)-N'-(7-(trifluoromethyl)quinolin-4-yl)carbamimidothioic acid

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 24h; Reflux;
DOI:10.1016/j.ejmech.2013.08.048

Reference yield:

: 346-55-4
4-chloro-7-trifluoromethyl quinoline

: 1491007-12-5
(E)-N-(4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)-N'-(7-(trifluoromethyl)quinolin-4-yl)carbamimidothioic acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetone / 1 h / Reflux

2: triethylamine / N,N-dimethyl-formamide / 24 h / Reflux

With triethylamine; In N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2013.08.048