N-[4-(2-[6-(4-aminopiperidino)-2-methyl-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]-N'-phenylurea

Base Information

Chemical Name:N-[4-(2-[6-(4-aminopiperidino)-2-methyl-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]-N'-phenylurea
CAS No.:1395051-23-6
Molecular Formula:C₂₆H₂₈N₈OS
Molecular Weight:500.627
Hs Code.:

Synonyms:N-[4-(2-[6-(4-aminopiperidino)-2-methyl-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]-N'-phenylurea

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Chemical Property of N-[4-(2-[6-(4-aminopiperidino)-2-methyl-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]-N'-phenylurea

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Technology Process of N-[4-(2-[6-(4-aminopiperidino)-2-methyl-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]-N'-phenylurea

There total 6 articles about N-[4-(2-[6-(4-aminopiperidino)-2-methyl-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]-N'-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₃₆N₈O₃S

: 1395051-23-6
N-[4-(2-[6-(4-aminopiperidino)-2-methyl-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]-N'-phenylurea

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/j.ejmech.2015.05.008

Reference yield:

: 1395052-25-1
N₂-(6-chloro-2-methyl-4-pyrimidinyl)-5-(4-aminophenyl)-1,3-thiazol-2-amine

: 1395051-23-6
N-[4-(2-[6-(4-aminopiperidino)-2-methyl-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]-N'-phenylurea

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 2 h / 80 °C

2: pyridine / 2 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With pyridine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2015.05.008

Reference yield:

: C₂₄H₃₁N₇O₂S

: 1395051-23-6
N-[4-(2-[6-(4-aminopiperidino)-2-methyl-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]-N'-phenylurea

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 2 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With pyridine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2015.05.008