methyl 2-{[4'-methoxy-(1,1'-biphenyl)-4-yl]-sulfonyl}-amino-5-(4-morpholino-phenyl)-pent-4-ynoate

Base Information

Chemical Name:methyl 2-{[4'-methoxy-(1,1'-biphenyl)-4-yl]-sulfonyl}-amino-5-(4-morpholino-phenyl)-pent-4-ynoate
CAS No.:291533-80-7
Molecular Formula:C₂₉H₃₀N₂O₆S
Molecular Weight:534.633
Hs Code.:

Synonyms:methyl 2-{[4'-methoxy-(1,1'-biphenyl)-4-yl]-sulfonyl}-amino-5-(4-morpholino-phenyl)-pent-4-ynoate

Suppliers and Price of methyl 2-{[4'-methoxy-(1,1'-biphenyl)-4-yl]-sulfonyl}-amino-5-(4-morpholino-phenyl)-pent-4-ynoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-{[4'-methoxy-(1,1'-biphenyl)-4-yl]-sulfonyl}-amino-5-(4-morpholino-phenyl)-pent-4-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-{[4'-methoxy-(1,1'-biphenyl)-4-yl]-sulfonyl}-amino-5-(4-morpholino-phenyl)-pent-4-ynoate

There total 7 articles about methyl 2-{[4'-methoxy-(1,1'-biphenyl)-4-yl]-sulfonyl}-amino-5-(4-morpholino-phenyl)-pent-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-amino-5-(4-morpholin-4-yl-phenyl)-pent-4-ynoic acid methyl ester

: 291533-80-7
methyl 2-{[4'-methoxy-(1,1'-biphenyl)-4-yl]-sulfonyl}-amino-5-(4-morpholino-phenyl)-pent-4-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / dioxane; H₂O

2: aq. Na₂CO₃; Pd(PPh₃)4 / benzene / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; In 1,4-dioxane; water; benzene; 1: Schotten-Baumann reaction / 2: Suzuki coupling;
DOI:10.1021/jm000477l

Reference yield:

: 291533-78-3
Methyl 2-N-boc-amino-5-(4-morpholinophenyl)-pent-4-ynoate

: 291533-80-7
methyl 2-{[4'-methoxy-(1,1'-biphenyl)-4-yl]-sulfonyl}-amino-5-(4-morpholino-phenyl)-pent-4-ynoate

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / methanol / 20 °C

2: Et₃N / dioxane; H₂O

3: aq. Na₂CO₃; Pd(PPh₃)4 / benzene / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium carbonate; triethylamine; In 1,4-dioxane; methanol; water; benzene; 2: Schotten-Baumann reaction / 3: Suzuki coupling;
DOI:10.1021/jm000477l

Reference yield:

: 50428-03-0
D,L-propargylglycine

: 291533-80-7
methyl 2-{[4'-methoxy-(1,1'-biphenyl)-4-yl]-sulfonyl}-amino-5-(4-morpholino-phenyl)-pent-4-ynoate

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / 16 h

2: 9.6 g / Et₃N / CH₂Cl₂ / 18 h

3: 72 percent / triethylamine; tetrakis(triphenylphosphene)palladium; copper(I) iodide / dimethylformamide / 20 °C

4: SOCl₂ / methanol / 20 °C

5: Et₃N / dioxane; H₂O

6: aq. Na₂CO₃; Pd(PPh₃)4 / benzene / Heating

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; benzene; 1: Williams esterification / 5: Schotten-Baumann reaction / 6: Suzuki coupling;
DOI:10.1021/jm000477l