1-((benzyloxy)methoxy)-3,5-dimethoxy-2-((4-methoxyphenyl)ethynyl)benzene

Base Information

Chemical Name:1-((benzyloxy)methoxy)-3,5-dimethoxy-2-((4-methoxyphenyl)ethynyl)benzene
CAS No.:1357016-31-9
Molecular Formula:C₂₅H₂₄O₅
Molecular Weight:404.463
Hs Code.:

Synonyms:1-((benzyloxy)methoxy)-3,5-dimethoxy-2-((4-methoxyphenyl)ethynyl)benzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-((benzyloxy)methoxy)-3,5-dimethoxy-2-((4-methoxyphenyl)ethynyl)benzene

Chemical Property:

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Technology Process of 1-((benzyloxy)methoxy)-3,5-dimethoxy-2-((4-methoxyphenyl)ethynyl)benzene

There total 3 articles about 1-((benzyloxy)methoxy)-3,5-dimethoxy-2-((4-methoxyphenyl)ethynyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 696-62-8
para-iodoanisole

: 1357016-30-8
1-((benzyloxy)methoxy)-2-ethynyl-3,5-dimethoxybenzene

: 1357016-31-9
1-((benzyloxy)methoxy)-3,5-dimethoxy-2-((4-methoxyphenyl)ethynyl)benzene

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jo202366c

Reference yield:

: 1357016-29-5
2-((benzyloxy)methoxy)-4,6-dimethoxybenzaldehyde

: 1357016-31-9
1-((benzyloxy)methoxy)-3,5-dimethoxy-2-((4-methoxyphenyl)ethynyl)benzene

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 14 h / 0 - 20 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; 1: Seyferth-Gilbert homologation / 2: Sonogashira coupling;
DOI:10.1021/jo202366c

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 1357016-31-9
1-((benzyloxy)methoxy)-3,5-dimethoxy-2-((4-methoxyphenyl)ethynyl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 13 h / 20 °C / Reflux; Inert atmosphere

2: potassium carbonate / methanol / 14 h / 0 - 20 °C / Inert atmosphere

3: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With dmap; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; 2: Seyferth-Gilbert homologation / 3: Sonogashira coupling;
DOI:10.1021/jo202366c