4-(3-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propyl)morpholine

Base Information

• Chemical Name: 4-(3-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propyl)morpholine
• CAS No.: 910462-33-8
• Molecular Formula: C₁₉H₃₀BNO₄
• Molecular Weight: 347.262
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID40405237
• Wikidata: Q82209688
• Mol file: 910462-33-8.mol

Synonyms:910462-33-8;4-(3-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propyl)morpholine;4-(3-Morpholinopropoxy)phenylboronic acid, pinacol ester;4-[3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propyl]morpholine;4-{3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propyl}morpholine;SCHEMBL701173;F1393-0014;4-(3-Morpholinopropoxy)phenylboronic acid pinacol ester;DTXSID40405237;CNKVMMVQJAQTCV-UHFFFAOYSA-N;MFCD04440858;AKOS016001016;BS-29692;CS-0174588;VU0489199-1;D93584;4-(3-Morpholin-4-ylpropoxy)benzeneboronic acid, pinacol ester;4-{3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-propyl}-morpholine;4-{3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxy]propyl}morpholine

Chemical Property of 4-(3-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propyl)morpholine

Chemical Property:

• Boiling Point: 474.7±40.0 °C(Predicted)
• PKA: 7.13±0.10(Predicted)
• PSA: 40.16000
• Density: 1.09±0.1 g/cm3(Predicted)
• LogP: 2.02480
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 347.2267886
• Heavy Atom Count: 25
• Complexity: 402

Purity/Quality:

96+% ^*data from raw suppliers

4-(3-Morpholin-4-ylpropoxy)benzeneboronic acid, pinacol ester 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC=C(C=C2)OCCCN3CCOCC3

Technology Process of 4-(3-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propyl)morpholine

There total 3 articles about 4-(3-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.5%

methanesulfonic acid 3-morpholin-4-yl-propyl ester (1018895-28-7) + 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (269409-70-3) → 4-{3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]propyl}morpholine (910462-33-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 8h;

DOI:10.1021/acs.jmedchem.7b00840

Reference yield: 57.0%

3-morpholin-4-ylpropan-1-ol (4441-30-9) + 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (269409-70-3) → 4-{3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]propyl}morpholine (910462-33-8)

Guidance literature:

With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

3-morpholin-4-ylpropan-1-ol (4441-30-9) → 4-{3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]propyl}morpholine (910462-33-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 70 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.7b00840

upstream raw materials:

3-morpholin-4-ylpropan-1-ol

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

methanesulfonic acid 3-morpholin-4-yl-propyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 910462-33-8 4-(3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propyl)morpholine

Send

Send

Metric Ton KG G Pound L ML

Send

Send