[(1R,6R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-6-hydroxymethyl-cyclohex-3-enyl]-methanol

Base Information

Chemical Name:[(1R,6R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-6-hydroxymethyl-cyclohex-3-enyl]-methanol
CAS No.:1028297-17-7
Molecular Formula:C₁₅H₃₀O₃Si
Molecular Weight:286.487
Hs Code.:

Synonyms:[(1R,6R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-6-hydroxymethyl-cyclohex-3-enyl]-methanol

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Chemical Property of [(1R,6R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-6-hydroxymethyl-cyclohex-3-enyl]-methanol

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Technology Process of [(1R,6R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-6-hydroxymethyl-cyclohex-3-enyl]-methanol

There total 1 articles about [(1R,6R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-6-hydroxymethyl-cyclohex-3-enyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: (1R,2R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-cyclohex-4-ene-1,2-dicarboxylic acid bis-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester

: 1028297-17-7
[(1R,6R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-6-hydroxymethyl-cyclohex-3-enyl]-methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 25 ℃;
DOI:10.1021/jm00072a027

Reference yield: 92.0%

: 108-24-7
acetic anhydride

: 1028297-17-7
[(1R,6R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-6-hydroxymethyl-cyclohex-3-enyl]-methanol

: Acetic acid (1R,6R)-6-acetoxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-3-enylmethyl ester

Guidance literature:: With pyridine; In tetrahydrofuran; at 25 ℃;
DOI:10.1021/jm00072a027

Reference yield:

: 1028297-17-7
[(1R,6R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-6-hydroxymethyl-cyclohex-3-enyl]-methanol

: ((1R,2R,5R)-2,5-Bis-phosphonomethyl-cyclohexylmethyl)-phosphonic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 92 percent / pyridine / tetrahydrofuran / 25 °C

2: 84 percent / TsOH / tetrahydrofuran; H₂O / 25 °C

3: 70 percent / SOCl₂, pyridine / tetrahydrofuran / 0 - 5 °C

4: 81 percent / 130 °C

5: 99 percent / K₂CO₃ / ethanol; H₂O / 25 °C

6: 86 percent / Et₃N / CH₂Cl₂ / 25 °C

7: 1.) Na / 2.) toluene, 85 deg C

8: 90 percent / H₂ / 10percent Pd/C / ethanol / 25 °C / 3620.04 Torr

9: conc. HCl / Heating

With pyridine; hydrogenchloride; thionyl chloride; hydrogen; sodium; potassium carbonate; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm00072a027