Technology Process of 4-[S-(3-bromophenyl)-N-(3-{N,N-bismethanesulfonylamino}benzene-sulfonyl)sulfoximino]-5-methylsulfanyl-thiophene-2-carboxamidine trifluoroacetate
There total 23 articles about 4-[S-(3-bromophenyl)-N-(3-{N,N-bismethanesulfonylamino}benzene-sulfonyl)sulfoximino]-5-methylsulfanyl-thiophene-2-carboxamidine trifluoroacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
dichloromethane;
at 20 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 1.5 h / -78 °C
1.2: -78 - 20 °C
2.1: copper(II) bis(trifluoromethanesulfonate) / acetonitrile / 1 h / 20 °C
3.1: tetrahydrofuran; methanol / 1.5 h / -78 - 20 °C
4.1: ammonia; ammonium formate / tetrahydrofuran; methanol / 16 h / 40 °C
5.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; methanol / 4 h / 20 °C
6.1: iron; ammonium chloride / methanol; water / 1 h / 80 °C / Heating / reflux
7.1: triethylamine / dichloromethane / 1.5 h / 20 °C
8.1: dichloromethane / 1.5 h / 20 °C
With
ammonia; isopropylmagnesium chloride; ammonium formate; iron; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine;
copper(II) bis(trifluoromethanesulfonate);
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C
2.1: bromine; sodium carbonate / 20 °C
3.1: isopropylmagnesium chloride / tetrahydrofuran / 1.5 h / -78 °C
3.2: -78 - 20 °C
4.1: copper(II) bis(trifluoromethanesulfonate) / acetonitrile / 1 h / 20 °C
5.1: tetrahydrofuran; methanol / 1.5 h / -78 - 20 °C
6.1: ammonia; ammonium formate / tetrahydrofuran; methanol / 16 h / 40 °C
7.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; methanol / 4 h / 20 °C
8.1: iron; ammonium chloride / methanol; water / 1 h / 80 °C / Heating / reflux
9.1: triethylamine / dichloromethane / 1.5 h / 20 °C
10.1: dichloromethane / 1.5 h / 20 °C
With
ammonia; bromine; isopropylmagnesium chloride; ammonium formate; iron; sodium carbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate;
copper(II) bis(trifluoromethanesulfonate);
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
