Technology Process of dimethyl (2R,3R,4S,5R)-2-acetoxy-3,4,5-tris(benzyloxy)cyclohexane-1,1-dicarboxylate
There total 20 articles about dimethyl (2R,3R,4S,5R)-2-acetoxy-3,4,5-tris(benzyloxy)cyclohexane-1,1-dicarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: mercury(II) chloride, calcium carbonate / acetonitrile; H2O / 0.5 h / Ambient temperature
2: 1.) triethylamine, 2.) acetic anhydride / 1.) pyridine, 30 h, RT, 2.) 40 h, RT
3: H2 / Raney nickel T-4 / ethanol / 1 h / 760 Torr / Ambient temperature
4: tetrabutylammonium fluoride / tetrahydrofuran / 2.5 h / Ambient temperature
5: 1.) pyridinium chlorochromate, molecular sieves, 2.) pyridine / 1.) RT, 15 h
With
pyridine; molecular sieve; tetrabutyl ammonium fluoride; hydrogen; acetic anhydride; triethylamine; pyridinium chlorochromate; calcium carbonate; mercury dichloride;
Raney nickel T-4;
In
tetrahydrofuran; ethanol; water; acetonitrile;
DOI:10.1021/jo00386a011
- Guidance literature:
-
Multi-step reaction with 7 steps
1: p-toluenesulfonic acid monohydrate / ethyl acetate; methanol / Ambient temperature
2: 93 percent / imidazole / dimethylformamide / Ambient temperature
3: mercury(II) chloride, calcium carbonate / acetonitrile; H2O / 0.5 h / Ambient temperature
4: 1.) triethylamine, 2.) acetic anhydride / 1.) pyridine, 30 h, RT, 2.) 40 h, RT
5: H2 / Raney nickel T-4 / ethanol / 1 h / 760 Torr / Ambient temperature
6: tetrabutylammonium fluoride / tetrahydrofuran / 2.5 h / Ambient temperature
7: 1.) pyridinium chlorochromate, molecular sieves, 2.) pyridine / 1.) RT, 15 h
With
pyridine; 1H-imidazole; molecular sieve; tetrabutyl ammonium fluoride; hydrogen; acetic anhydride; toluene-4-sulfonic acid; triethylamine; pyridinium chlorochromate; calcium carbonate; mercury dichloride;
Raney nickel T-4;
In
tetrahydrofuran; methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00386a011
- Guidance literature:
-
Multi-step reaction with 3 steps
1: H2 / Raney nickel T-4 / ethanol / 1 h / 760 Torr / Ambient temperature
2: tetrabutylammonium fluoride / tetrahydrofuran / 2.5 h / Ambient temperature
3: 1.) pyridinium chlorochromate, molecular sieves, 2.) pyridine / 1.) RT, 15 h
With
pyridine; molecular sieve; tetrabutyl ammonium fluoride; hydrogen; pyridinium chlorochromate;
Raney nickel T-4;
In
tetrahydrofuran; ethanol;
DOI:10.1021/jo00386a011
