N-{9-[(3aR,4R,6R,6aR)-6-(2,2-Dibromo-vinyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

Base Information

Chemical Name:N-{9-[(3aR,4R,6R,6aR)-6-(2,2-Dibromo-vinyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide
CAS No.:170996-41-5
Molecular Formula:C₂₁H₁₉Br₂N₅O₄
Molecular Weight:565.221
Hs Code.:

Synonyms:N-{9-[(3aR,4R,6R,6aR)-6-(2,2-Dibromo-vinyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

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Chemical Property of N-{9-[(3aR,4R,6R,6aR)-6-(2,2-Dibromo-vinyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

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Technology Process of N-{9-[(3aR,4R,6R,6aR)-6-(2,2-Dibromo-vinyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

There total 1 articles about N-{9-[(3aR,4R,6R,6aR)-6-(2,2-Dibromo-vinyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39947-04-1
N-6-benzoyl-2',3'-O-isopropylideneadenosine

: 170996-41-5
N-{9-[(3aR,4R,6R,6aR)-6-(2,2-Dibromo-vinyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: Me₂SO, N,N'-dicyclohexylcarbodiimide, Cl₂CHCO₂H / 1.5 h / Ambient temperature

2: CH₂Cl₂ / 4 h

With dichloro-acetic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jm9801410

Reference yield: 53.0%

: 170996-41-5
N-{9-[(3aR,4R,6R,6aR)-6-(2,2-Dibromo-vinyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

: 136676-14-7
N-[9-((3aR,4R,6R,6aR)-6-Ethynyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h;
DOI:10.1021/jm980163m

Reference yield:

: 170996-41-5
N-{9-[(3aR,4R,6R,6aR)-6-(2,2-Dibromo-vinyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

: N-[9-((3aR,4R,6R,6aR)-6-Iodoethynyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / BuLi / hexane; tetrahydrofuran / 2 h / -78 °C

2: 1.) aq. NH₃, AgNO₃, 2.) N-iodosuccinimide / 1.) acetone, 5 min, 2.) acetone, 30 min

With ammonium hydroxide; N-iodo-succinimide; n-butyllithium; silver nitrate; In tetrahydrofuran; hexane;
DOI:10.1021/jm980163m