N-(3-bromo-benzo[b]thiophen-2-yl)-N-(4-fluoro-benzyl)-benzenesulfonamide

Base Information

• Chemical Name: N-(3-bromo-benzo[b]thiophen-2-yl)-N-(4-fluoro-benzyl)-benzenesulfonamide
• CAS No.: 1104623-17-7
• Molecular Formula: C₂₁H₁₅BrFNO₂S₂
• Molecular Weight: 476.39

Synonyms:N-(3-bromo-benzo[b]thiophen-2-yl)-N-(4-fluoro-benzyl)-benzenesulfonamide

Chemical Property of N-(3-bromo-benzo[b]thiophen-2-yl)-N-(4-fluoro-benzyl)-benzenesulfonamide

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Technology Process of N-(3-bromo-benzo[b]thiophen-2-yl)-N-(4-fluoro-benzyl)-benzenesulfonamide

There total 5 articles about N-(3-bromo-benzo[b]thiophen-2-yl)-N-(4-fluoro-benzyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

N-(3-bromo-benzo[b]thiophen-2-yl)-benzenesulfonamide (1104630-86-5) + 4-Fluorobenzyl bromide (459-46-1) → N-(3-bromo-benzo[b]thiophen-2-yl)-N-(4-fluoro-benzyl)-benzenesulfonamide (1104623-17-7)

Guidance literature:

N-(3-bromo-benzo[b]thiophen-2-yl)-benzenesulfonamide; With lithium hexamethyldisilazane; In tetrahydrofuran; hexanes; at -78 ℃; for 0.25h;

4-Fluorobenzyl bromide; In tetrahydrofuran; hexanes; at -78 - 20 ℃; for 144h;

Reference yield:

2-(tert-butoxycarbonylamino)benzothiophene (89673-36-9) → N-(3-bromo-benzo[b]thiophen-2-yl)-N-(4-fluoro-benzyl)-benzenesulfonamide (1104623-17-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane / 20 °C

2.1: pyridine / 2 h / 0 - 20 °C

3.1: bromine / dichloromethane / 0.25 h / 0 °C

4.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 0.25 h / -78 °C

4.2: 144 h / 20 °C

With hydrogenchloride; bromine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; pyridine; hexane; dichloromethane;

Reference yield:

N-benzo[b]thiophen-2-yl-benzenesulfonamide (1104394-29-7) → N-(3-bromo-benzo[b]thiophen-2-yl)-N-(4-fluoro-benzyl)-benzenesulfonamide (1104623-17-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromine / dichloromethane / 0.25 h / 0 °C

2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 0.25 h / -78 °C

2.2: 144 h / 20 °C

With bromine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane;

upstream raw materials:

N-(3-bromo-benzo[b]thiophen-2-yl)-benzenesulfonamide

4-Fluorobenzyl bromide

2-(tert-butoxycarbonylamino)benzothiophene

N-benzo[b]thiophen-2-yl-benzenesulfonamide

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