C₁₂H₁₅⁽²⁾HO₄

Base Information

• Chemical Name: C₁₂H₁₅⁽²⁾HO₄
• CAS No.: 870104-89-5
• Molecular Formula: C₁₂H₁₆O₄
• Molecular Weight: 225.249
• Mol file: 870104-89-5.mol

Synonyms:C₁₂H₁₅⁽²⁾HO₄

Chemical Property of C₁₂H₁₅⁽²⁾HO₄

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of C₁₂H₁₅⁽²⁾HO₄

There total 3 articles about C₁₂H₁₅⁽²⁾HO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(S)-2-hydroxypropanal (S)-α-methoxyphenylacetic acid ester (870104-87-3) → C12H15(2)HO4 (870104-89-5)

Guidance literature:

With (S)-[1,1']-binaphthalenyl-2,2'-diol; tributyltin deuteride; trifluoroacetic acid; titanium(IV) isopropylate; 4 A molecular sieve; In diethyl ether;

DOI:10.1002/chem.200500181

Reference yield:

(S)-Methoxy-phenyl-acetic acid (S)-2-hydroxy-1-methyl-ethyl ester (870104-85-1) → C12H15(2)HO4 (870104-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / Dess-Martin reagent / CH₂Cl₂

2: 65 percent / Bu₃SnD; (S)-BINOL; TFA / Ti(O-i-Pr)4; 4 Angstroem molecular sieves / diethyl ether

With (S)-[1,1']-binaphthalenyl-2,2'-diol; tributyltin deuteride; Dess-Martin periodane; trifluoroacetic acid; titanium(IV) isopropylate; 4 A molecular sieve; In diethyl ether; dichloromethane;

DOI:10.1002/chem.200500181

Reference yield:

(2S)-1-{[(1,1-dimethylethyl)dimethylsilyl]oxy}-2-propanol (S)-α-methoxyphenylacetic acid ester (870104-83-9) → C12H15(2)HO4 (870104-89-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / AcCl; MeOH / 0 °C

2: 89 percent / Dess-Martin reagent / CH₂Cl₂

3: 65 percent / Bu₃SnD; (S)-BINOL; TFA / Ti(O-i-Pr)4; 4 Angstroem molecular sieves / diethyl ether

With methanol; (S)-[1,1']-binaphthalenyl-2,2'-diol; tributyltin deuteride; Dess-Martin periodane; acetyl chloride; trifluoroacetic acid; titanium(IV) isopropylate; 4 A molecular sieve; In diethyl ether; dichloromethane;

DOI:10.1002/chem.200500181

upstream raw materials:

(S)-2-hydroxypropanal (S)-α-methoxyphenylacetic acid ester

(S)-Methoxy-phenyl-acetic acid (S)-2-hydroxy-1-methyl-ethyl ester

(2S)-1-{[(1,1-dimethylethyl)dimethylsilyl]oxy}-2-propanol (S)-α-methoxyphenylacetic acid ester

Refernces