2-{(methyl)[3-(3-(piperidin-1-ylmethyl)phenoxy)benzyl]amino}-1-(4-(methylsulfanyl)phenyl)ethan-1-ol

Base Information

Chemical Name:2-{(methyl)[3-(3-(piperidin-1-ylmethyl)phenoxy)benzyl]amino}-1-(4-(methylsulfanyl)phenyl)ethan-1-ol
CAS No.:1086400-87-4
Molecular Formula:C₂₉H₃₆N₂O₂S
Molecular Weight:476.683
Hs Code.:

Synonyms:2-{(methyl)[3-(3-(piperidin-1-ylmethyl)phenoxy)benzyl]amino}-1-(4-(methylsulfanyl)phenyl)ethan-1-ol

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Chemical Property of 2-{(methyl)[3-(3-(piperidin-1-ylmethyl)phenoxy)benzyl]amino}-1-(4-(methylsulfanyl)phenyl)ethan-1-ol

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Technology Process of 2-{(methyl)[3-(3-(piperidin-1-ylmethyl)phenoxy)benzyl]amino}-1-(4-(methylsulfanyl)phenyl)ethan-1-ol

There total 9 articles about 2-{(methyl)[3-(3-(piperidin-1-ylmethyl)phenoxy)benzyl]amino}-1-(4-(methylsulfanyl)phenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1086400-86-3
2-{(methyl)[3-(3-(piperidin-1-ylmethyl)phenoxy)benzyl]amino}-1-(4-methylsulfanyl-phenyl)-ethan-1-one

: 1086400-87-4
2-{(methyl)[3-(3-(piperidin-1-ylmethyl)phenoxy)benzyl]amino}-1-(4-(methylsulfanyl)phenyl)ethan-1-ol

Guidance literature:: 2-{(methyl)[3-(3-(piperidin-1-ylmethyl)phenoxy)benzyl]amino}-1-(4-methylsulfanyl-phenyl)-ethan-1-one; With sodium tetrahydroborate; In ethanol; for 1h;

With sodium hydroxide; In ethanol; water;

Reference yield:

: 110-89-4
piperidine

: 1086400-87-4
2-{(methyl)[3-(3-(piperidin-1-ylmethyl)phenoxy)benzyl]amino}-1-(4-(methylsulfanyl)phenyl)ethan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 72 h / 0 - 20 °C

2.1: caesium carbonate / copper(l) iodide / 1-Methylpyrrolidine / 4 h / 195 °C / Microwave irradiation

3.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1 h / -78 °C

3.2: 1 h / -78 °C

4.1: sodium tetrahydroborate / methanol; water / 3.5 h / 0 °C

4.2: 1 h

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h

6.1: sodium tetrahydroborate / ethanol / 1 h

With sodium tetrahydroborate; oxalyl dichloride; sodium tris(acetoxy)borohydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; copper(l) iodide; In tetrahydrofuran; 1-Methylpyrrolidine; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1086400-87-4
2-{(methyl)[3-(3-(piperidin-1-ylmethyl)phenoxy)benzyl]amino}-1-(4-(methylsulfanyl)phenyl)ethan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 72 h / 0 - 20 °C

2.1: caesium carbonate / copper(l) iodide / 1-Methylpyrrolidine / 4 h / 195 °C / Microwave irradiation

3.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1 h / -78 °C

3.2: 1 h / -78 °C

4.1: sodium tetrahydroborate / methanol; water / 3.5 h / 0 °C

4.2: 1 h

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h

6.1: sodium tetrahydroborate / ethanol / 1 h

With sodium tetrahydroborate; oxalyl dichloride; sodium tris(acetoxy)borohydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; copper(l) iodide; In tetrahydrofuran; 1-Methylpyrrolidine; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;