N-(3,4-dihydroxyphenethyl)-6-(2-(2,5-diiodothiophen-3-yl)ethoxy)hexanamide

Base Information

Chemical Name:N-(3,4-dihydroxyphenethyl)-6-(2-(2,5-diiodothiophen-3-yl)ethoxy)hexanamide
CAS No.:1426826-61-0
Molecular Formula:C₂₀H₂₅I₂NO₄S
Molecular Weight:629.298
Hs Code.:

Synonyms:N-(3,4-dihydroxyphenethyl)-6-(2-(2,5-diiodothiophen-3-yl)ethoxy)hexanamide

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Chemical Property of N-(3,4-dihydroxyphenethyl)-6-(2-(2,5-diiodothiophen-3-yl)ethoxy)hexanamide

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Technology Process of N-(3,4-dihydroxyphenethyl)-6-(2-(2,5-diiodothiophen-3-yl)ethoxy)hexanamide

There total 3 articles about N-(3,4-dihydroxyphenethyl)-6-(2-(2,5-diiodothiophen-3-yl)ethoxy)hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1426826-60-9
6-(2-(2,5-diiodothiophen-3-yl)ethoxy)hexanoic acid

: 62-31-7
dopamine hydrochloride

: 1426826-61-0
N-(3,4-dihydroxyphenethyl)-6-(2-(2,5-diiodothiophen-3-yl)ethoxy)hexanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1h;
DOI:10.1002/adfm.201202132

Reference yield:

: 361203-25-0
3-(2-((6-bromohexyl)oxy)ethyl)thiophene

: 1426826-61-0
N-(3,4-dihydroxyphenethyl)-6-(2-(2,5-diiodothiophen-3-yl)ethoxy)hexanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-iodo-succinimide / dichloromethane; acetic acid / 0 °C / Darkness

2.1: potassium acetate / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

2.2: 2 h / 60 °C / Inert atmosphere

3.1: Jones reagent / acetone / 0 °C

4.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 0 °C

With N-iodo-succinimide; Jones reagent; potassium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1002/adfm.201202132

Reference yield:

: 1426826-59-6
3-(2-((6-bromohexyl)oxy)ethyl)-2,5-diiodothiophene

: 1426826-61-0
N-(3,4-dihydroxyphenethyl)-6-(2-(2,5-diiodothiophen-3-yl)ethoxy)hexanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

1.2: 2 h / 60 °C / Inert atmosphere

2.1: Jones reagent / acetone / 0 °C

3.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 0 °C

With Jones reagent; potassium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; acetone;
DOI:10.1002/adfm.201202132