(2R,3S)-3-[N-(t-butoxycarbonyl)-2-methyl-3-phenylaziridine-2-carbonyl]-oxazolidin-2-one

Base Information

Chemical Name:(2R,3S)-3-[N-(t-butoxycarbonyl)-2-methyl-3-phenylaziridine-2-carbonyl]-oxazolidin-2-one
CAS No.:1309658-16-9
Molecular Formula:C₁₈H₂₂N₂O₅
Molecular Weight:346.383
Hs Code.:

Synonyms:(2R,3S)-3-[N-(t-butoxycarbonyl)-2-methyl-3-phenylaziridine-2-carbonyl]-oxazolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-3-[N-(t-butoxycarbonyl)-2-methyl-3-phenylaziridine-2-carbonyl]-oxazolidin-2-one

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Technology Process of (2R,3S)-3-[N-(t-butoxycarbonyl)-2-methyl-3-phenylaziridine-2-carbonyl]-oxazolidin-2-one

There total 8 articles about (2R,3S)-3-[N-(t-butoxycarbonyl)-2-methyl-3-phenylaziridine-2-carbonyl]-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1218811-94-9
3-(2-diazopropanoyl)oxazolidin-2-one

: 150884-50-7
benzaldehyde N-boc imine

: 1309658-16-9
(2R,3S)-3-[N-(t-butoxycarbonyl)-2-methyl-3-phenylaziridine-2-carbonyl]-oxazolidin-2-one

Guidance literature:: With C₃₈H₂₅BO₃; C₄₄H₃₀B₂O₅; (2S)-(-)-3,3'-diphenyl-(2,2'-binaphthalene)-1,1'-diol; In dichloromethane; at -78 ℃; for 6h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja203754p

Reference yield:

: 1218811-94-9
3-(2-diazopropanoyl)oxazolidin-2-one

: 150884-50-7
benzaldehyde N-boc imine

: 1309658-16-9
(2R,3S)-3-[N-(t-butoxycarbonyl)-2-methyl-3-phenylaziridine-2-carbonyl]-oxazolidin-2-one

: 1309658-14-7
(2S,3R)-3-[N-(t-butoxycarbonyl)-2-methyl-3-phenylaziridine-2-carbonyl]-oxazolidin-2-one

Guidance literature:: With (S)-[3,3’-diphenyl-1,1’-binaphthalen-2,2’-yl]-N-triflyl phosphoramide; In dichloromethane; at -78 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja203901h

Reference yield:

: rac-(2R,3S)-3-[N-(t-butoxycarbonyl)-2-methyl-3-phenylaziridine-2-carbonyl]-oxazolidin-2-one

: 1309658-16-9
(2R,3S)-3-[N-(t-butoxycarbonyl)-2-methyl-3-phenylaziridine-2-carbonyl]-oxazolidin-2-one

: 1309658-14-7
(2S,3R)-3-[N-(t-butoxycarbonyl)-2-methyl-3-phenylaziridine-2-carbonyl]-oxazolidin-2-one

: C₁₈H₂₄N₂O₆

: 1310929-29-3
C₁₈H₂₄N₂O₆

Guidance literature:: With (S)-[3,3’-diphenyl-1,1’-binaphthalen-2,2’-yl]-N-triflyl phosphoramide; water; In dichloromethane; at -78 ℃; for 2h; optical yield given as %ee; Inert atmosphere; Resolution of racemate;
DOI:10.1021/ja203901h