Technology Process of 1α,25-di-tetrahydropyranyloxy-5Z-vitamin D3
There total 7 articles about 1α,25-di-tetrahydropyranyloxy-5Z-vitamin D3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 7 steps
1.1: sulfur dioxide / Reflux
2.1: 1H-imidazole / N,N-dimethyl-formamide
3.1: sodium hydrogencarbonate / ethanol / Reflux
4.1: selenium(IV) oxide / dichloromethane / 0.5 h / Reflux; Inert atmosphere
4.2: 1 h / Reflux; Inert atmosphere
5.1: anthracene; triethylamine / toluene / 1.25 h / UV-irradiation
6.1: pyridinium p-toluenesulfonate / dichloromethane
7.1: tetrabutyl ammonium fluoride / tetrahydrofuran
With
1H-imidazole; selenium(IV) oxide; anthracene; sulfur dioxide; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.02.025
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridinium p-toluenesulfonate / dichloromethane
2: tetrabutyl ammonium fluoride / tetrahydrofuran
With
tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2011.02.025
