4-(5-iodo-2-benzimidazolyl)-3-(2-methylphenyl)butanoic acid monohydrochloride

Base Information

• Chemical Name: 4-(5-iodo-2-benzimidazolyl)-3-(2-methylphenyl)butanoic acid monohydrochloride
• CAS No.: 1221962-38-4
• Molecular Formula: C₁₈H₁₇IN₂O₂*ClH
• Molecular Weight: 456.711
• Mol file: 1221962-38-4.mol

Synonyms:4-(5-iodo-2-benzimidazolyl)-3-(2-methylphenyl)butanoic acid monohydrochloride

Chemical Property of 4-(5-iodo-2-benzimidazolyl)-3-(2-methylphenyl)butanoic acid monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(5-iodo-2-benzimidazolyl)-3-(2-methylphenyl)butanoic acid monohydrochloride

There total 5 articles about 4-(5-iodo-2-benzimidazolyl)-3-(2-methylphenyl)butanoic acid monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-iodo-2-nitroaniline (20691-72-9) → 4-(5-iodo-2-benzimidazolyl)-3-(2-methylphenyl)butanoic acid monohydrochloride (1221962-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tin(II) chloride dihdyrate / ethanol / 2 h / 75 °C

2.1: dichloromethane / 1 h / 20 °C

2.2: 1 h / Reflux

With tin(II) chloride dihdyrate; In ethanol; dichloromethane;

Reference yield:

C17H17IN2O3 + C17H17IN2O3 → 4-(5-iodo-2-benzimidazolyl)-3-(2-methylphenyl)butanoic acid monohydrochloride (1221962-38-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 1h; Heating; Reflux;

Reference yield:

2-methylphenyl aldehyde (529-20-4) → 4-(5-iodo-2-benzimidazolyl)-3-(2-methylphenyl)butanoic acid monohydrochloride (1221962-38-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: piperidine / ethanol / 48 h / 20 °C

1.2: 2 h / Reflux

1.3: Cooling with ice

2.1: acetyl chloride / 2 h / Reflux

3.1: dichloromethane / 1 h / 20 °C

3.2: 1 h / Reflux

With piperidine; acetyl chloride; In ethanol; dichloromethane;

upstream raw materials:

4-iodo-2-nitroaniline

4-iodobenzene-1,2-diamine

2-methylphenyl aldehyde

3-(2-methylphenyl)pentan-1,5-dioic acid