4-Hydroxy-5-iodo-2-isobutyl-6-trifluoromethyl-isophthalic acid dimethyl ester

Base Information

• Chemical Name: 4-Hydroxy-5-iodo-2-isobutyl-6-trifluoromethyl-isophthalic acid dimethyl ester
• CAS No.: 153706-54-8
• Molecular Formula: C₁₅H₁₆F₃IO₅
• Molecular Weight: 460.189
• Mol file: 153706-54-8.mol

Synonyms:4-Hydroxy-5-iodo-2-isobutyl-6-trifluoromethyl-isophthalic acid dimethyl ester

Chemical Property of 4-Hydroxy-5-iodo-2-isobutyl-6-trifluoromethyl-isophthalic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Hydroxy-5-iodo-2-isobutyl-6-trifluoromethyl-isophthalic acid dimethyl ester

There total 1 articles about 4-Hydroxy-5-iodo-2-isobutyl-6-trifluoromethyl-isophthalic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-methoxycarbonyl-2-oxopropylidene)triphenylphosphorane (98815-59-9) + Methyl 5-methyl-2-(trifluoroacetyl)-2-hexenoate (132368-88-8) → dimethyl 4-hydroxy-2-(2-methylpropyl)-6-(trifluoromethyl)-1,3-benzenedicarboxylate (153706-53-7) + 4-Hydroxy-5-iodo-2-isobutyl-6-trifluoromethyl-isophthalic acid dimethyl ester (153706-54-8)

Guidance literature:

With iodine; sodium methylate; Multistep reaction. Title compound not separated from byproducts; 1.) benzene, 4 h, RT, 2.) MeOH, RT, 3 h;

DOI:10.1080/00397919308013806

Reference yield:

4-Hydroxy-5-iodo-2-isobutyl-6-trifluoromethyl-isophthalic acid dimethyl ester (153706-54-8) → dimethyl 4-hydroxy-2-(2-methylpropyl)-6-(trifluoromethyl)-1,3-benzenedicarboxylate (153706-53-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 24h; under 2280 Torr;

DOI:10.1080/00397919308013806

Reference yield:

4-Hydroxy-5-iodo-2-isobutyl-6-trifluoromethyl-isophthalic acid dimethyl ester (153706-54-8) → dimethyl 4-methoxy-2-(2-methylpropyl)-6-(trifluoromethyl)-1,3-benzenedicarboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 24 h / 2280 Torr

2: 88 percent / K₂CO₃ / acetone / 16 h / Heating

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; acetone;

DOI:10.1080/00397919308013806

upstream raw materials:

(3-methoxycarbonyl-2-oxopropylidene)triphenylphosphorane

Methyl 5-methyl-2-(trifluoroacetyl)-2-hexenoate

Downstream raw materials:

dimethyl 4-hydroxy-2-(2-methylpropyl)-6-(trifluoromethyl)-1,3-benzenedicarboxylate