(6R,7R)-3-Hydroxy-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

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Chemical Name:(6R,7R)-3-Hydroxy-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
CAS No.:131065-42-4
Molecular Formula:C₄₅H₃₇N₅O₆S₂
Molecular Weight:807.951
Hs Code.:

(6R,7R)-3-Hydroxy-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Synonyms:(6R,7R)-3-Hydroxy-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

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Chemical Property of (6R,7R)-3-Hydroxy-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

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Technology Process of (6R,7R)-3-Hydroxy-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

There total 2 articles about (6R,7R)-3-Hydroxy-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64485-90-1
2-(2-aminothiazol-4-yl)-2-(methoxy)iminoacetic acid

: 131065-42-4
(6R,7R)-3-Hydroxy-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DMF, trichloromethyl chloroformate / CH₂Cl₂ / 1 h / 0 °C

2: 1.) N,O-bis(trimethylsilyl)acetamide / 1.) CH₂Cl₂, room temperature, 1 h, 2.) -40 deg C, 10 min

With N,O-bis-(trimethylsilyl)-acetamide; N,N-dimethyl-formamide; trichloromethyl chloroformate; In dichloromethane;
DOI:10.1016/S0968-0896(98)00050-9

Reference yield:

: 76609-91-1
2-(2-tritylamino-4-thiazolyl)-2-methoxyiminoacetyl chloride

: 51761-91-2
(6R)-7t-amino-3,8-dioxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2ξ-carboxylic acid benzhydryl ester; toluene-4-sulfonate

: 131065-42-4
(6R,7R)-3-Hydroxy-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: With N,O-bis-(trimethylsilyl)-acetamide; Yield given. Multistep reaction; 1.) CH₂Cl₂, room temperature, 1 h, 2.) -40 deg C, 10 min;
DOI:10.1016/S0968-0896(98)00050-9