3-ethyl-6-methyl-1H-pyridin-2-one

Base Information

• Chemical Name: 3-ethyl-6-methyl-1H-pyridin-2-one
• CAS No.: 90086-88-7
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.181
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID00383961
• Wikidata: Q82175801
• Mol file: 90086-88-7.mol

Synonyms:90086-88-7;3-ethyl-6-methyl-1H-pyridin-2-one;3-Ethyl-6-methylpyridin-2(1H)-one;3-ethyl-6-methyl-1,2-dihydropyridin-2-one;3-ethyl-6-methyl-2-pyridinol;SCHEMBL1738125;SCHEMBL12806957;DTXSID00383961;CHEBI:194784;NHYGCOYUWGZZQX-UHFFFAOYSA-N;3-Ethyl-2-hydroxy-6-methylpyridine;AKOS006229480;FT-0702204

Chemical Property of 3-ethyl-6-methyl-1H-pyridin-2-one

Chemical Property:

• PSA: 32.86000
• LogP: 1.24570
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 213

Purity/Quality:

98%min ^*data from raw suppliers

3-ETHYL-6-METHYL-1,2-DIHYDROPYRIDIN-2-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=CC=C(NC1=O)C

Technology Process of 3-ethyl-6-methyl-1H-pyridin-2-one

There total 4 articles about 3-ethyl-6-methyl-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-ethyl-6-methylpyridin-2-amine (41995-31-7) → 3-ethyl-6-methylpyridin-2(1H)-one (90086-88-7)

Guidance literature:

3-ethyl-6-methylpyridin-2-amine; With sulfuric acid; sodium nitrite; In water; at 0 - 20 ℃; for 20h;

With sodium hydroxide; In water; pH=9.0;

Reference yield:

3-ethyl-6-methylpyridin-2-amine (41995-31-7) → 3-ethyl-6-methyl-pyridin-2-ol (90086-88-7)

Guidance literature:

With sulfuric acid; sodium nitrite;

Reference yield:

5-ethyl-2-methyl-pyridine (104-90-5) → 3-ethyl-6-methyl-pyridin-2-ol (90086-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: vaseline oil; sodium amide / 180 - 190 °C

2: sodium nitrite; diluted sulfuric acid

With vaseline oil; sulfuric acid; sodium amide; sodium nitrite;

upstream raw materials:

3-ethyl-6-methylpyridin-2-amine

5-ethyl-2-methyl-pyridine

Downstream raw materials:

3-bromo-5-ethyl-6-methoxy-2-methylpyridine