Technology Process of (1R,2S,4S)-2,4,5-Tris-benzyloxy-1-vinyl-pentylamine
There total 6 articles about (1R,2S,4S)-2,4,5-Tris-benzyloxy-1-vinyl-pentylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrazine hydrate;
In
ethanol;
for 3h;
Heating;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 75 percent / 4-(dimethylamino)pyridine, pyridine / tetrahydrofuran / 22 h / 22 °C
2: 100 percent / p-TsOH / tetrahydrofuran / 14 h / 22 °C
3: 1) NaOMe, 2) oxalyl chloride, DMSO, diethylisopropylamine / 1) MeOH, 22 deg C, 14 h, 2) CH2Cl2, 3 h
4: tetrahydrofuran-d8 / 0.5 h / 0 °C
5: 52 percent / triphenylphosphane, diethyl azodicarboxylate / tetrahydrofuran / -20 °C
6: 87 percent / hydrazine hydrate / ethanol / 3 h / Heating
With
pyridine; dmap; oxalyl dichloride; N,N-diethyl-N-isopropylamine; sodium methylate; toluene-4-sulfonic acid; hydrazine hydrate; dimethyl sulfoxide; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; tetrahydrofuran-d8; ethanol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 52 percent / triphenylphosphane, diethyl azodicarboxylate / tetrahydrofuran / -20 °C
2: 87 percent / hydrazine hydrate / ethanol / 3 h / Heating
With
hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; ethanol;
