N-{4-[(4-tert-butyloxycarbonylamino)butanoylamino]benzoyl}methionine methyl ester

Base Information

Chemical Name:N-{4-[(4-tert-butyloxycarbonylamino)butanoylamino]benzoyl}methionine methyl ester
CAS No.:309957-33-3
Molecular Formula:C₂₂H₃₃N₃O₆S
Molecular Weight:467.587
Hs Code.:

Synonyms:N-{4-[(4-tert-butyloxycarbonylamino)butanoylamino]benzoyl}methionine methyl ester

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Chemical Property of N-{4-[(4-tert-butyloxycarbonylamino)butanoylamino]benzoyl}methionine methyl ester

Chemical Property:

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Technology Process of N-{4-[(4-tert-butyloxycarbonylamino)butanoylamino]benzoyl}methionine methyl ester

There total 1 articles about N-{4-[(4-tert-butyloxycarbonylamino)butanoylamino]benzoyl}methionine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 57294-38-9
N-(tert-butoxycarbonyl)-4-aminobutanoic acid

: 154383-61-6
N-(4-aminobenzoyl)-L-methionine methyl ester

: 309957-33-3
N-{4-[(4-tert-butyloxycarbonylamino)butanoylamino]benzoyl}methionine methyl ester

Guidance literature:: N-(tert-butoxycarbonyl)-4-aminobutanoic acid; With 4-methyl-morpholine; isobutyl chloroformate; In N,N-dimethyl-formamide; at -15 ℃; for 0.0833333h;

N-(4-aminobenzoyl)-L-methionine methyl ester; In N,N-dimethyl-formamide; at -15 - 20 ℃;
DOI:10.1016/S0968-0896(00)00173-5

Reference yield:

: 309957-33-3
N-{4-[(4-tert-butyloxycarbonylamino)butanoylamino]benzoyl}methionine methyl ester

: (S)-2-[4-(4-Amino-butyrylamino)-benzoylamino]-4-methylsulfanyl-butyric acid methyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;
DOI:10.1016/S0968-0896(00)00173-5

Reference yield:

: 309957-33-3
N-{4-[(4-tert-butyloxycarbonylamino)butanoylamino]benzoyl}methionine methyl ester

: (S)-2-[4-(4-Hexadecanoylamino-butyrylamino)-benzoylamino]-4-methylsulfanyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / dioxane / 2 h / 20 °C

2: 978 mg / N-methylmorpholine / CH₂Cl₂ / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; In 1,4-dioxane; dichloromethane; 1: carbamate cleavage / 2: Acylation;
DOI:10.1016/S0968-0896(00)00173-5