diethyl N-<4-<<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>thio>benzoyl>-L-glutamate

Base Information

• Chemical Name: diethyl N-<4-<<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>thio>benzoyl>-L-glutamate
• CAS No.: 133446-89-6
• Molecular Formula: C₂₆H₂₉N₃O₆S
• Molecular Weight: 511.599
• Mol file: 133446-89-6.mol

Synonyms:diethyl N-<4-<<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>thio>benzoyl>-L-glutamate

Chemical Property of diethyl N-<4-<<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>thio>benzoyl>-L-glutamate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of diethyl N-<4-<<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>thio>benzoyl>-L-glutamate

There total 1 articles about diethyl N-<4-<<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>thio>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline (112888-43-4) + Tetraethyl 4,4'-Dithiobis(N-benzoyl-L-glutamate) (56527-28-7) → diethyl N-<4-<<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>thio>benzoyl>-L-glutamate (133446-89-6)

Guidance literature:

With sodium tetrahydroborate; Yield given. Multistep reaction; 1.) EtOH, 10 min, 2.) DMF, 20 deg C, 16 h;

DOI:10.1021/jm00111a042

Reference yield: 65.0%

diethyl N-<4-<<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>thio>benzoyl>-L-glutamate (133446-89-6) → (S)-2-[4-(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethylsulfanyl)-benzoylamino]-pentanedioic acid (133446-58-9)

Guidance literature:

With sodium hydroxide; In ethanol; for 2h;

DOI:10.1021/jm00111a042

upstream raw materials:

4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline

Tetraethyl 4,4'-Dithiobis(N-benzoyl-L-glutamate)

Downstream raw materials:

(S)-2-[4-(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethylsulfanyl)-benzoylamino]-pentanedioic acid