2-(2-([1,1'-biphenyl]-4-carbonyl)-3-(nitromethyl)-2,3-dihydro-1H-inden-1-yl)-1-([1,1'-biphenyl]-4-yl)ethan-1-one

Base Information

• Chemical Name: 2-(2-([1,1'-biphenyl]-4-carbonyl)-3-(nitromethyl)-2,3-dihydro-1H-inden-1-yl)-1-([1,1'-biphenyl]-4-yl)ethan-1-one
• CAS No.: 1542158-94-0
• Molecular Formula: C₃₇H₂₉NO₄
• Molecular Weight: 551.642

Synonyms:2-(2-([1,1'-biphenyl]-4-carbonyl)-3-(nitromethyl)-2,3-dihydro-1H-inden-1-yl)-1-([1,1'-biphenyl]-4-yl)ethan-1-one

Chemical Property of 2-(2-([1,1'-biphenyl]-4-carbonyl)-3-(nitromethyl)-2,3-dihydro-1H-inden-1-yl)-1-([1,1'-biphenyl]-4-yl)ethan-1-one

Chemical Property:

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Technology Process of 2-(2-([1,1'-biphenyl]-4-carbonyl)-3-(nitromethyl)-2,3-dihydro-1H-inden-1-yl)-1-([1,1'-biphenyl]-4-yl)ethan-1-one

There total 3 articles about 2-(2-([1,1'-biphenyl]-4-carbonyl)-3-(nitromethyl)-2,3-dihydro-1H-inden-1-yl)-1-([1,1'-biphenyl]-4-yl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

nitromethane (75-52-5) + C36H26O2 (1542159-09-0) → 2-(2-([1,1'-biphenyl]-4-carbonyl)-3-(nitromethyl)-2,3-dihydro-1H-inden-1-yl)-1-([1,1'-biphenyl]-4-yl)ethan-1-one (1542158-94-0)

Guidance literature:

With N-(9-epi-hydroquinidin-9-yl)-N'-[3,5-bis(CF₃)phenyl]thiourea; In toluene; at 40 ℃; for 48h; enantioselective reaction; Molecular sieve;

DOI:10.1002/ejoc.201301860

Reference yield:

1-([1,1'-biphenyl]-4-yl)-2-(triphenyl-λ5-phosphaneylidene)ethan-1-one (2959-60-6) → 2-(2-([1,1'-biphenyl]-4-carbonyl)-3-(nitromethyl)-2,3-dihydro-1H-inden-1-yl)-1-([1,1'-biphenyl]-4-yl)ethan-1-one (1542158-94-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 16 h / Reflux

2: N-(9-epi-hydroquinidin-9-yl)-N'-[3,5-bis(CF₃)phenyl]thiourea / toluene / 48 h / 40 °C / Molecular sieve

With N-(9-epi-hydroquinidin-9-yl)-N'-[3,5-bis(CF₃)phenyl]thiourea; In dichloromethane; toluene; 2: |Michael Addition;

DOI:10.1002/ejoc.201301860

Reference yield:

o-phthalic dicarboxaldehyde (643-79-8) → 2-(2-([1,1'-biphenyl]-4-carbonyl)-3-(nitromethyl)-2,3-dihydro-1H-inden-1-yl)-1-([1,1'-biphenyl]-4-yl)ethan-1-one (1542158-94-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 16 h / Reflux

2: N-(9-epi-hydroquinidin-9-yl)-N'-[3,5-bis(CF₃)phenyl]thiourea / toluene / 48 h / 40 °C / Molecular sieve

With N-(9-epi-hydroquinidin-9-yl)-N'-[3,5-bis(CF₃)phenyl]thiourea; In dichloromethane; toluene; 2: |Michael Addition;

DOI:10.1002/ejoc.201301860

upstream raw materials:

nitromethane

C₃₆H₂₆O₂

1-([1,1'-biphenyl]-4-yl)-2-(triphenyl-λ⁵-phosphaneylidene)ethan-1-one

o-phthalic dicarboxaldehyde

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