3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(methyl(3-(trifluoromethyl)phenyl)amino)benzoic acid trifluoroacetic acid salt

Base Information

Chemical Name:3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(methyl(3-(trifluoromethyl)phenyl)amino)benzoic acid trifluoroacetic acid salt
CAS No.:1445879-32-2
Molecular Formula:C₂HF₃O₂*C₃₃H₂₉F₃N₆O₆S
Molecular Weight:808.715
Hs Code.:

3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(methyl(3-(trifluoromethyl)phenyl)amino)benzoic acid trifluoroacetic acid salt

Synonyms:3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(methyl(3-(trifluoromethyl)phenyl)amino)benzoic acid trifluoroacetic acid salt

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Chemical Property of 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(methyl(3-(trifluoromethyl)phenyl)amino)benzoic acid trifluoroacetic acid salt

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Technology Process of 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(methyl(3-(trifluoromethyl)phenyl)amino)benzoic acid trifluoroacetic acid salt

There total 9 articles about 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(methyl(3-(trifluoromethyl)phenyl)amino)benzoic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₁₃F₃N₂O₂

: 1445880-62-5
4-chloro-N-cyclopropyl-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

: 76-05-1
trifluoroacetic acid

: 1445879-32-2
3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(methyl(3-(trifluoromethyl)phenyl)amino)benzoic acid trifluoroacetic acid salt

Guidance literature:: C₁₅H₁₃F₃N₂O₂; 4-chloro-N-cyclopropyl-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide; With acetic acid;

With water; sodium hydroxide; In methanol;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445879-32-2
3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(methyl(3-(trifluoromethyl)phenyl)amino)benzoic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: chlorosulfonic acid / 18 h / 100 °C

2.1: trichlorophosphate / 3 h / Reflux

3.1: triethylamine / dichloromethane / 1 h / 0 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 80 °C

5.1: acetic acid

5.3: preparative HPLC, YMC 75 X 30 mm column

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; triethylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1445791-54-7
ethyl 3-nitro-5-((3-(trifluoromethyl)phenyl)amino)benzoate

: 1445879-32-2
3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(methyl(3-(trifluoromethyl)phenyl)amino)benzoic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere

2.1: acetic acid; palladium 10% on activated carbon; hydrogen / 2 h / 20 °C

3.1: acetic acid

3.3: preparative HPLC, YMC 75 X 30 mm column

With palladium 10% on activated carbon; hydrogen; sodium hydride; acetic acid; In N,N-dimethyl-formamide; mineral oil;