Technology Process of 3-(dibutylamino)-5-(methylsulfonyl)-4-phenoxybenzoic acid sodium salt
There total 10 articles about 3-(dibutylamino)-5-(methylsulfonyl)-4-phenoxybenzoic acid sodium salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-(dibutylamino)-5-(methylsulfonyl)-4-phenoxybenzoic acid;
With
sodium hydrogencarbonate;
In
water;
at 20 ℃;
for 0.25h;
With
sodium chloride;
In
water;
at 20 ℃;
for 20h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydrogencarbonate / water / 85 °C
2.1: thionyl chloride / 60 °C
3.1: ammonium chloride; iron / water; ethanol / 2.25 h / 85 °C
4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C
5.1: lithium hydroxide / methanol; tetrahydrofuran / 2 h
6.1: trifluoroacetic acid / acetonitrile / 0.5 h / 0 °C
6.2: 0 - 20 °C
7.1: sodium hydrogencarbonate / water / 0.25 h / 20 °C
7.2: 20 h / 20 °C
With
thionyl chloride; sodium tris(acetoxy)borohydride; iron; sodium hydrogencarbonate; ammonium chloride; trifluoroacetic acid; lithium hydroxide;
In
tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sodium sulfite / water / 3 h / 0 - 20 °C
2.1: sodium hydroxide / water; methanol / 72 h / 20 °C
3.1: sulfuric acid; nitric acid / 1 h / 0 - 110 °C
4.1: sodium hydrogencarbonate / water / 85 °C
5.1: thionyl chloride / 60 °C
6.1: ammonium chloride; iron / water; ethanol / 2.25 h / 85 °C
7.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C
8.1: lithium hydroxide / methanol; tetrahydrofuran / 2 h
9.1: trifluoroacetic acid / acetonitrile / 0.5 h / 0 °C
9.2: 0 - 20 °C
10.1: sodium hydrogencarbonate / water / 0.25 h / 20 °C
10.2: 20 h / 20 °C
With
thionyl chloride; sulfuric acid; nitric acid; sodium tris(acetoxy)borohydride; iron; sodium hydrogencarbonate; ammonium chloride; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; sodium sulfite;
In
tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; acetonitrile;
