(3R)-3-[(4-chlorobenzyl)sulfanyl]-1,3-diphenylpropan-1-one

Base Information

• Chemical Name: (3R)-3-[(4-chlorobenzyl)sulfanyl]-1,3-diphenylpropan-1-one
• CAS No.: 1255154-24-5
• Molecular Formula: C₂₂H₁₉ClOS
• Molecular Weight: 366.911
• Mol file: 1255154-24-5.mol

Synonyms:(3R)-3-[(4-chlorobenzyl)sulfanyl]-1,3-diphenylpropan-1-one

Chemical Property of (3R)-3-[(4-chlorobenzyl)sulfanyl]-1,3-diphenylpropan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (3R)-3-[(4-chlorobenzyl)sulfanyl]-1,3-diphenylpropan-1-one

There total 6 articles about (3R)-3-[(4-chlorobenzyl)sulfanyl]-1,3-diphenylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(4-chlorophenyl)methanethiol (6258-66-8) + 1,3-diphenyl-propen-3-one (614-47-1) → (3R)-3-[(4-chlorobenzyl)sulfanyl]-1,3-diphenylpropan-1-one (1255154-24-5)

Guidance literature:

With C₃₈H₅₄ClFeN₂O₂; In 1,2-dichloro-ethane; at -5 ℃; Temperature; enantioselective reaction;

DOI:10.1055/s-0035-1562103

Reference yield: 89.0%

benzalacetophenone (94-41-7) + (4-chlorophenyl)methanethiol (6258-66-8) → (3R)-3-[(4-chlorobenzyl)sulfanyl]-1,3-diphenylpropan-1-one (1255154-24-5)

Guidance literature:

With pyridine; water; (S, S)-6,6’-bis(1-hydroxy-2,2-dimethylpropyl)-2,2’-bipyridine; scandium tris(trifluoromethanesulfonate); at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction;

DOI:10.1039/c2ob26264a

Reference yield:

benzalacetophenone (94-41-7) + (4-chlorophenyl)methanethiol (6258-66-8) → (3R)-3-[(4-chlorobenzyl)sulfanyl]-1,3-diphenylpropan-1-one (1255154-24-5) + (3S)-3-[(4-chlorobenzyl)sulfanyl]-1,3-diphenylpropan-1-one

Guidance literature:

benzalacetophenone; With C₃₆H₄₀Cl₂FeN₃O₃; In water; for 0.0833333h;

(4-chlorophenyl)methanethiol; In water; at 25 ℃; for 36h; Overall yield = 56 percent; enantioselective reaction;

DOI:10.1039/d0gc00949k

upstream raw materials:

(4-chlorophenyl)methanethiol

1,3-diphenyl-propen-3-one

benzalacetophenone

benzaldehyde