5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-1,3-diaza-2-thia-tricyclo[3.3.1.1^3,7]decan-6-one 2,2-dioxide

Base Information

• Chemical Name: 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-1,3-diaza-2-thia-tricyclo[3.3.1.1^3,7]decan-6-one 2,2-dioxide
• CAS No.: 1604777-36-7
• Molecular Formula: C₂₃H₂₀F₆N₂O₃S
• Molecular Weight: 518.48

Synonyms:5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-1,3-diaza-2-thia-tricyclo[3.3.1.1^3,7]decan-6-one 2,2-dioxide

Chemical Property of 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-1,3-diaza-2-thia-tricyclo[3.3.1.1^3,7]decan-6-one 2,2-dioxide

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Technology Process of 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-1,3-diaza-2-thia-tricyclo[3.3.1.1^3,7]decan-6-one 2,2-dioxide

There total 3 articles about 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-1,3-diaza-2-thia-tricyclo[3.3.1.1^3,7]decan-6-one 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

5,7-bis[[4-(trifluoromethyl)phenyl]methyl]-1,3-diazatricyclo[3.3.1.13,7]decan-6-one (1053242-58-2) → 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-1,3-diaza-2-thia-tricyclo[3.3.1.13,7]decan-6-one 2,2-dioxide (1604777-36-7)

Guidance literature:

With pyridine; sulfuryl dichloride; In acetonitrile; at 20 ℃; Reflux;

DOI:10.2174/15734064113099900002

Reference yield:

1,5-bis[4-(trifluoromethyl)phenyl]-3-pentanone (1053242-55-9) → 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-1,3-diaza-2-thia-tricyclo[3.3.1.13,7]decan-6-one 2,2-dioxide (1604777-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / ethanol / 15 h / Reflux

2: pyridine; sulfuryl dichloride / acetonitrile / 20 °C / Reflux

With pyridine; sulfuryl dichloride; acetic acid; In ethanol; acetonitrile; 1: |Mannich Aminomethylation;

DOI:10.2174/15734064113099900002

Reference yield:

4-(trifluoromethyl)benzylic alcohol (349-95-1) → 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-1,3-diaza-2-thia-tricyclo[3.3.1.13,7]decan-6-one 2,2-dioxide (1604777-36-7)

Guidance literature:

Multi-step reaction with 3 steps

1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; triphenylphosphine; potassium hydroxide / 100 °C

2: acetic acid / ethanol / 15 h / Reflux

3: pyridine; sulfuryl dichloride / acetonitrile / 20 °C / Reflux

With pyridine; bis(1,5-cyclooctadiene)diiridium(I) dichloride; sulfuryl dichloride; acetic acid; triphenylphosphine; potassium hydroxide; In ethanol; acetonitrile; 2: |Mannich Aminomethylation;

DOI:10.2174/15734064113099900002

upstream raw materials:

5,7-bis[[4-(trifluoromethyl)phenyl]methyl]-1,3-diazatricyclo[3.3.1.1^3,7]decan-6-one

4-(trifluoromethyl)benzylic alcohol

1,5-bis[4-(trifluoromethyl)phenyl]-3-pentanone

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