2-[methyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl 4-trifluoromethoxybenzoate

Base Information

Chemical Name:2-[methyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl 4-trifluoromethoxybenzoate
CAS No.:635751-28-9
Molecular Formula:C₂₈H₂₄F₆N₄O₆S
Molecular Weight:658.578
Hs Code.:

2-[methyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl 4-trifluoromethoxybenzoate

Synonyms:2-[methyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl 4-trifluoromethoxybenzoate

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Chemical Property of 2-[methyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl 4-trifluoromethoxybenzoate

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Technology Process of 2-[methyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl 4-trifluoromethoxybenzoate

There total 3 articles about 2-[methyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl 4-trifluoromethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₁ClF₃NO₄

: 138530-94-6
(R)-lansoprazole

: 635751-28-9
2-[methyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl 4-trifluoromethoxybenzoate

Guidance literature:: With triethylamine; dmap; In tetrahydrofuran; at 60 ℃; for 4.5h;

Reference yield:

: 635750-81-1
2-(methylamino)ethyl 4-trifluoromethoxybenzoate hydrochloride

: 32315-10-9
bis(trichloromethyl) carbonate

: 138530-94-6
(R)-lansoprazole

: 635751-28-9
2-[methyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl 4-trifluoromethoxybenzoate

Guidance literature:: 2-(methylamino)ethyl 4-trifluoromethoxybenzoate hydrochloride; bis(trichloromethyl) carbonate; With pyridine; triethylamine; In tetrahydrofuran; at 20 ℃; for 2h; Ice-cooling;

(R)-lansoprazole; With triethylamine; dmap; In tetrahydrofuran; at 60 ℃; for 4.5h;

Reference yield:

: 635750-81-1
2-(methylamino)ethyl 4-trifluoromethoxybenzoate hydrochloride

: 635751-28-9
2-[methyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl 4-trifluoromethoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / tetrahydrofuran / 0.5 h / Cooling with ice

1.2: 1.5 h / 20 °C

2.1: dmap; triethylamine / tetrahydrofuran / 4.5 h / 60 °C

With pyridine; dmap; triethylamine; In tetrahydrofuran;