N²-acetyl-6-O-diphenylcarbamoyl-9-(5'-O-benzoyl-3'-C-cyano-2',3'-didehydro-2',3'-dideoxy-β-L-ribofuranosyl)guanosine

Base Information

• Chemical Name: N²-acetyl-6-O-diphenylcarbamoyl-9-(5'-O-benzoyl-3'-C-cyano-2',3'-didehydro-2',3'-dideoxy-β-L-ribofuranosyl)guanosine
• CAS No.: 612485-33-3
• Molecular Formula: C₃₃H₂₅N₇O₆
• Molecular Weight: 615.605

Synonyms:N²-acetyl-6-O-diphenylcarbamoyl-9-(5'-O-benzoyl-3'-C-cyano-2',3'-didehydro-2',3'-dideoxy-β-L-ribofuranosyl)guanosine

Chemical Property of N²-acetyl-6-O-diphenylcarbamoyl-9-(5'-O-benzoyl-3'-C-cyano-2',3'-didehydro-2',3'-dideoxy-β-L-ribofuranosyl)guanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-acetyl-6-O-diphenylcarbamoyl-9-(5'-O-benzoyl-3'-C-cyano-2',3'-didehydro-2',3'-dideoxy-β-L-ribofuranosyl)guanosine

There total 4 articles about N²-acetyl-6-O-diphenylcarbamoyl-9-(5'-O-benzoyl-3'-C-cyano-2',3'-didehydro-2',3'-dideoxy-β-L-ribofuranosyl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N2-acetyl-6-O-diphenylcarbamoyl-9-(2'-O-acetyl-5'-O-benzoyl-3'-C-cyano-3'-deoxy-β-L-ribofuranosyl)guanine (612485-23-1) → N2-acetyl-6-O-diphenylcarbamoyl-9-(5'-O-benzoyl-3'-C-cyano-2',3'-didehydro-2',3'-dideoxy-β-L-ribofuranosyl)guanosine (612485-33-3)

Guidance literature:

With dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/S0040-4020(03)01074-3

Reference yield:

3-C-cyano-3-deoxy-1,2-O-isopropylidene-α-L-ribofuranose → N2-acetyl-6-O-diphenylcarbamoyl-9-(5'-O-benzoyl-3'-C-cyano-2',3'-didehydro-2',3'-dideoxy-β-L-ribofuranosyl)guanosine (612485-33-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 95 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

2: CF₃CO₂H / H₂O / 6 h

3: 32 g / pyridine / 12 h / 20 °C

4: 62 percent / N,O-bis(trimethylsilyl)acetamide; TMSOTf / acetonitrile / 24 h / Heating

5: 93 percent / 4-(dimethylamino)pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 1 h / 20 °C

With pyridine; dmap; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In dichloromethane; water; acetonitrile;

DOI:10.1016/S0040-4020(03)01074-3

Reference yield:

Benzoic acid (2R,3R,4S)-3-cyano-4,5-dihydroxy-tetrahydro-furan-2-ylmethyl ester (1027222-97-4) → N2-acetyl-6-O-diphenylcarbamoyl-9-(5'-O-benzoyl-3'-C-cyano-2',3'-didehydro-2',3'-dideoxy-β-L-ribofuranosyl)guanosine (612485-33-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 32 g / pyridine / 12 h / 20 °C

2: 62 percent / N,O-bis(trimethylsilyl)acetamide; TMSOTf / acetonitrile / 24 h / Heating

3: 93 percent / 4-(dimethylamino)pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 1 h / 20 °C

With pyridine; dmap; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4020(03)01074-3

upstream raw materials:

N²-acetyl-6-O-diphenylcarbamoyl-9-(2'-O-acetyl-5'-O-benzoyl-3'-C-cyano-3'-deoxy-β-L-ribofuranosyl)guanine

Benzoic acid (2R,3R,4S)-3-cyano-4,5-dihydroxy-tetrahydro-furan-2-ylmethyl ester

5-O-benzoyl-3-C-cyano-3-deoxy-1,2-O-isopropylidene-α-L-ribofuranose

Downstream raw materials:

N²-acetyl-9-(5'-O-benzoyl-3'-C-cyano-2',3'-didehydro-2',3'-dideoxy-β-L-ribofuranosyl)guanosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 612485-33-3 N²-acetyl-6-O-diphenylcarbamoyl-9-(5'-O-benzoyl-3'-C-cyano-2',3'-didehydro-2',3'-dideoxy-β-L-ribofuranosyl)guanosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send