tert-butyl ((3S,4R)-4-{[(4-ethylphenyl)sulfonyl]amino}-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-6-yl)acetate

Base Information

Chemical Name:tert-butyl ((3S,4R)-4-{[(4-ethylphenyl)sulfonyl]amino}-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-6-yl)acetate
CAS No.:912666-40-1
Molecular Formula:C₂₅H₃₃NO₆S
Molecular Weight:475.606
Hs Code.:

Synonyms:tert-butyl ((3S,4R)-4-{[(4-ethylphenyl)sulfonyl]amino}-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-6-yl)acetate

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Chemical Property of tert-butyl ((3S,4R)-4-{[(4-ethylphenyl)sulfonyl]amino}-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-6-yl)acetate

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Technology Process of tert-butyl ((3S,4R)-4-{[(4-ethylphenyl)sulfonyl]amino}-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-6-yl)acetate

There total 6 articles about tert-butyl ((3S,4R)-4-{[(4-ethylphenyl)sulfonyl]amino}-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-6-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 912666-38-7
tert-butyl [(3S,4R)-4-amino-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-6-yl]-acetate

: 16712-69-9
p-ethylbenzenesulfonyl chloride

: 912666-40-1
tert-butyl ((3S,4R)-4-{[(4-ethylphenyl)sulfonyl]amino}-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-6-yl)acetate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

: 912666-34-3
tert-butyl (2,2-dimethyl-2H-chromen-6-yl)acetate

: 912666-40-1
tert-butyl ((3S,4R)-4-{[(4-ethylphenyl)sulfonyl]amino}-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-6-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine N-oxide; sodium hypochlorite; disodium hydrogenphosphate / (S,S)-(+)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexyanediaminomanganese(III)chloride / dichloromethane; water / 4.75 h / 0 °C

2: ammonia; water / ethanol / 20 °C

3: triethylamine / dichloromethane / 5 h / 20 °C

With pyridine N-oxide; sodium hypochlorite; disodium hydrogenphosphate; ammonia; water; triethylamine; (S,S)-(+)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexyanediaminomanganese(III)chloride; In ethanol; dichloromethane; water; 1: Jacobsen Epoxidation;

Reference yield:

: 107-86-8
3,3-dimethyl acrylaldehyde

: 912666-40-1
tert-butyl ((3S,4R)-4-{[(4-ethylphenyl)sulfonyl]amino}-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-6-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: phenylboronic acid / toluene / 7 h / Heating / reflux

1.2: 7 h / Heating / reflux

2.1: sodium hydroxide; ethanol; water / 0.5 h / 20 °C

2.2: pH 2.0

3.1: sulfuric acid / dichloromethane / 6 h / -10 - 20 °C

4.1: pyridine N-oxide; sodium hypochlorite; disodium hydrogenphosphate / (S,S)-(+)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexyanediaminomanganese(III)chloride / dichloromethane; water / 4.75 h / 0 °C

5.1: ammonia; water / ethanol / 20 °C

6.1: triethylamine / dichloromethane / 5 h / 20 °C

With pyridine N-oxide; sodium hydroxide; sodium hypochlorite; disodium hydrogenphosphate; ethanol; sulfuric acid; ammonia; water; triethylamine; (S,S)-(+)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexyanediaminomanganese(III)chloride; phenylboronic acid; In ethanol; dichloromethane; water; toluene; 4.1: Jacobsen Epoxidation;