2-chloro-[1,2,4]triazolo[1,5-a]pyridine

Base Information

• Chemical Name: 2-chloro-[1,2,4]triazolo[1,5-a]pyridine
• CAS No.: 698-43-1
• Molecular Formula: C₆H₄ClN₃
• Molecular Weight: 153.571
• Mol file: 698-43-1.mol

Synonyms:2-chloro-[1,2,4]triazolo[1,5-a]pyridine

Chemical Property of 2-chloro-[1,2,4]triazolo[1,5-a]pyridine

Chemical Property:

• PKA: 0.55±0.30(Predicted)
• Density: 1.51±0.1 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-[1,2,4]triazolo[1,5-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-[1,2,4]triazolo[1,5-a]pyridine

There total 4 articles about 2-chloro-[1,2,4]triazolo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.2%

(Z)-N'-hydroxy-N-(pyridin-2-yl)carbamimidic chloride → 2-chloro-[1,2,4]triazolo[1,5-a]pyridine (698-43-1)

Guidance literature:

With trifluoroacetic anhydride; In tetrahydrofuran; at 0 - 20 ℃; for 3.5h; Inert atmosphere;

Reference yield: 67.0%

2-amino-s-triazolo-<1,5-a>-pyridne (874-46-4) → 2-chloro-[1,2,4]triazolo[1,5-a]pyridine (698-43-1)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; acetonitrile; at 20 ℃; Cooling with ice;

Reference yield:

2-aminopyridine (504-29-0) → 2-chloro-[1,2,4]triazolo[1,5-a]pyridine (698-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 4 h / 20 °C

1.2: 20 °C / Reflux

2.1: sodium nitrite; hydrogenchloride / water; acetonitrile / 20 °C / Cooling with ice

With hydrogenchloride; sodium nitrite; In dichloromethane; water; acetonitrile;

upstream raw materials:

2-amino-s-triazolo-<1,5-a>-pyridne

2-aminopyridine

Refernces

• 1、 -. "Green phosphorescent host material and OLED luminescent device containing the same". Paragraph 0041-0046. . Retrieved 2021/01/30.