2,2-Dimethyl-butyric acid (1R,2S,5R,6S)-2-[2-(4-methoxy-phenoxy)-ethyl]-5-phenylcarbamoyloxy-6-propyl-cyclohex-3-enylmethyl ester

Base Information

Chemical Name:2,2-Dimethyl-butyric acid (1R,2S,5R,6S)-2-[2-(4-methoxy-phenoxy)-ethyl]-5-phenylcarbamoyloxy-6-propyl-cyclohex-3-enylmethyl ester
CAS No.:157117-10-7
Molecular Formula:C₃₂H₄₃NO₆
Molecular Weight:537.697
Hs Code.:

Synonyms:2,2-Dimethyl-butyric acid (1R,2S,5R,6S)-2-[2-(4-methoxy-phenoxy)-ethyl]-5-phenylcarbamoyloxy-6-propyl-cyclohex-3-enylmethyl ester

Suppliers and Price of 2,2-Dimethyl-butyric acid (1R,2S,5R,6S)-2-[2-(4-methoxy-phenoxy)-ethyl]-5-phenylcarbamoyloxy-6-propyl-cyclohex-3-enylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,2-Dimethyl-butyric acid (1R,2S,5R,6S)-2-[2-(4-methoxy-phenoxy)-ethyl]-5-phenylcarbamoyloxy-6-propyl-cyclohex-3-enylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-butyric acid (1R,2S,5R,6S)-2-[2-(4-methoxy-phenoxy)-ethyl]-5-phenylcarbamoyloxy-6-propyl-cyclohex-3-enylmethyl ester

There total 21 articles about 2,2-Dimethyl-butyric acid (1R,2S,5R,6S)-2-[2-(4-methoxy-phenoxy)-ethyl]-5-phenylcarbamoyloxy-6-propyl-cyclohex-3-enylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 103-71-9
phenyl isocyanate

: 157117-09-4
2,2-Dimethyl-butyric acid (1R,2S,5R,6S)-5-hydroxy-2-[2-(4-methoxy-phenoxy)-ethyl]-6-propyl-cyclohex-3-enylmethyl ester

: 157117-10-7
2,2-Dimethyl-butyric acid (1R,2S,5R,6S)-2-[2-(4-methoxy-phenoxy)-ethyl]-5-phenylcarbamoyloxy-6-propyl-cyclohex-3-enylmethyl ester

Guidance literature:: With pyridine; dmap;
DOI:10.1016/S0040-4039(00)75797-2

Reference yield:

: 33208-47-8
4-O-benzyl-1,6:2,3-dianhydro-β-D-mannopyranose

: 157117-10-7
2,2-Dimethyl-butyric acid (1R,2S,5R,6S)-2-[2-(4-methoxy-phenoxy)-ethyl]-5-phenylcarbamoyloxy-6-propyl-cyclohex-3-enylmethyl ester

Guidance literature:: Multi-step reaction with 23 steps

1: diethyl ether / Ambient temperature

2: Et₃N / DMAP / CH₂Cl₂ / Ambient temperature

4: DEAD-Ph₃P / CH₂Cl₂ / Ambient temperature

5: H₂ / Pd/C / methanol

6: Et₃N / CH₂Cl₂ / -10 °C

7: MeONa / methanol / Ambient temperature

8: diethyl ether / Ambient temperature

9: H₂ / Pd/C / methanol

10: H⁽¹⁺⁾

11: pyridine

12: Swern oxidation

13: MeLi / tetrahydrofuran / -78 °C

14: methylaluminum bis-(4-bromo-2,6-di-tert-butyl-phenoxide) (MABR) / CH₂Cl₂ / -78 °C

15: NaBH₄ / 0.25 h / -20 °C

16: 92 percent / MsCl, Et₃N, DMAP / CH₂Cl₂

17: Bu₄NF / tetrahydrofuran

18: Bu₃P / tetrahydrofuran / 1 h / Ambient temperature

19: 1.) NaIO₄; 2.) Et₃N / 1.) MeOH; 2.) PhCH₃, reflux

20: 86 percent / Hg(OTFA)2 / H₂O; acetone / 1 h / slow addition of the substrate to catalyst

21: 93 percent / MsCl, Et₃N / CH₂Cl₂ / -10 deg C up to RT

22: CeCl₃*7H₂O, NaBH₄ / methanol

23: 98 percent / DMAP/pyridine

With pyridine; dmap; sodium tetrahydroborate; sodium periodate; cerium(III) chloride; tributylphosphine; tetrabutyl ammonium fluoride; methyllithium; hydrogen; sodium methylate; hydrogen cation; methanesulfonyl chloride; methylaluminium bis(4-bromo-2,6-di-tert.-butylphenoxide); triethylamine; triphenylphosphine; diethylazodicarboxylate; dmap; palladium on activated charcoal; mercury(II) trifluoroacetate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone;
DOI:10.1016/S0040-4039(00)75797-2

Reference yield:

: 157116-99-9
(1R,2R,4R,5R,6R)-5-[2-(4-Methoxy-phenoxy)-ethyl]-3,7,9-trioxa-tricyclo[4.2.1.0^2,4]nonane

: 157117-10-7
2,2-Dimethyl-butyric acid (1R,2S,5R,6S)-2-[2-(4-methoxy-phenoxy)-ethyl]-5-phenylcarbamoyloxy-6-propyl-cyclohex-3-enylmethyl ester

Guidance literature:: Multi-step reaction with 16 steps

1: diethyl ether / Ambient temperature

2: H₂ / Pd/C / methanol

3: H⁽¹⁺⁾

4: pyridine

5: Swern oxidation

6: MeLi / tetrahydrofuran / -78 °C

7: methylaluminum bis-(4-bromo-2,6-di-tert-butyl-phenoxide) (MABR) / CH₂Cl₂ / -78 °C

8: NaBH₄ / 0.25 h / -20 °C

9: 92 percent / MsCl, Et₃N, DMAP / CH₂Cl₂

10: Bu₄NF / tetrahydrofuran

11: Bu₃P / tetrahydrofuran / 1 h / Ambient temperature

12: 1.) NaIO₄; 2.) Et₃N / 1.) MeOH; 2.) PhCH₃, reflux

13: 86 percent / Hg(OTFA)2 / H₂O; acetone / 1 h / slow addition of the substrate to catalyst

14: 93 percent / MsCl, Et₃N / CH₂Cl₂ / -10 deg C up to RT

15: CeCl₃*7H₂O, NaBH₄ / methanol

16: 98 percent / DMAP/pyridine

With pyridine; dmap; sodium tetrahydroborate; sodium periodate; cerium(III) chloride; tributylphosphine; tetrabutyl ammonium fluoride; methyllithium; hydrogen; hydrogen cation; methanesulfonyl chloride; methylaluminium bis(4-bromo-2,6-di-tert.-butylphenoxide); triethylamine; palladium on activated charcoal; mercury(II) trifluoroacetate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone;
DOI:10.1016/S0040-4039(00)75797-2