tert-butyl 5-bromo-4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-ylcarbamate

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Chemical Name:tert-butyl 5-bromo-4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-ylcarbamate
CAS No.:1355336-19-4
Molecular Formula:C₁₉H₂₁BrN₄O₃S
Molecular Weight:465.371
Hs Code.:

Synonyms:tert-butyl 5-bromo-4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-ylcarbamate

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Chemical Property of tert-butyl 5-bromo-4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-ylcarbamate

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Technology Process of tert-butyl 5-bromo-4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-ylcarbamate

There total 2 articles about tert-butyl 5-bromo-4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1355336-18-3
tert-butyl 4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-ylcarbamate

: 1355336-19-4
tert-butyl 5-bromo-4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-ylcarbamate

Guidance literature:: With N-Bromosuccinimide; In chloroform; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1262849-13-7
4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-amine

: 1355336-19-4
tert-butyl 5-bromo-4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / dichloromethane / 20 °C / Inert atmosphere

2: N-Bromosuccinimide / chloroform / 1 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; dmap; In dichloromethane; chloroform;

Reference yield:

: 1355336-19-4
tert-butyl 5-bromo-4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-ylcarbamate

: 1355336-21-8
1-(2-amino-4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-5-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 0.67 h / 100 °C / Inert atmosphere; microwave irradiation

1.2: 0.33 h / 20 °C

2.1: hydrogenchloride; water / 0.33 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide;