6-bromo-2,3-dihydro-1H-inden-1-amine

Base Information

• Chemical Name: 6-bromo-2,3-dihydro-1H-inden-1-amine
• CAS No.: 907973-36-8
• Molecular Formula: C9H10 Br N
• Molecular Weight: 248.54734
• Hs Code.: 2921499090
• European Community (EC) Number: 809-647-0
• DSSTox Substance ID: DTXSID20585662
• Mol file: 907973-36-8.mol

Synonyms:6-bromo-2,3-dihydro-1H-inden-1-amine;907973-36-8;6-BROMO-INDAN-1-YLAMINE;6-bromoindan-1-amine;MFCD07373953;SCHEMBL4014236;DTXSID20585662;DUPHONQIBOZOHL-UHFFFAOYSA-N;6-Bromo-indan-1-ylamine, AldrichCPR;AKOS005265819;AB38388;PB13067;PB13072;AM804529;AS-39518;SY240457;CS-0101126

Chemical Property of 6-bromo-2,3-dihydro-1H-inden-1-amine

Chemical Property:

• PSA: 26.02000
• LogP: 3.09540
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 210.99966
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-2,3-dihydro-1H-inden-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(C1N)C=C(C=C2)Br

Technology Process of 6-bromo-2,3-dihydro-1H-inden-1-amine

There total 4 articles about 6-bromo-2,3-dihydro-1H-inden-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

6-bromoindan-1-one (14548-39-1) → 6-bromoindan-1-amine (907973-36-8,1213110-51-0)

Guidance literature:

With ammonium formate; sodium cyanoborohydride; In methanol;

DOI:10.1016/j.bmcl.2007.03.076

Reference yield:

6-bromo-2,3-dihydro-1H-inden-1-one oxime → 6-bromoindan-1-amine (907973-36-8,1213110-51-0)

Guidance literature:

With acetic acid; zinc; at 70 ℃; for 1h;

DOI:10.1002/anie.201914623

Reference yield:

(±)-N-(6-bromo-2,3-dihydro-1H-inden-1-yl)-2-methylpropane-2-sulfinamide → 6-bromoindan-1-amine (907973-36-8,1213110-51-0)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃; for 18h;

DOI:10.1021/acs.jmedchem.9b01573

upstream raw materials:

6-bromoindan-1-one

Refernces

• 1、 Cinelli, Maris A.,Reidl, Cory T.,Li, Huiying,Chreifi, Georges,Poulos, Thomas L.,Silverman, Richard B.. "First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate". . p. 4528 - 4554. Retrieved 2020/05/05.
• 2、 Bakir, Farid,Kher, Sunil,Pannala, Madhavi,Wilson, Norma,Nguyen, Trang,Sircar, Ila,Takedomi, Kei,Fukushima, Chiaki,Zapf, James,Xu, Kui,Zhang, Shao-Hui,Liu, Juping,Morera, Lisa,Schneider, Lisa,Sakurai, Naoki,Jack, Rick,Cheng, Jie-Fei. "Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists". . p. 3473 - 3479. Retrieved 2008/09/19.