1-[4-(1H-Imidazol-4-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-thiourea

Base Information

• Chemical Name: 1-[4-(1H-Imidazol-4-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-thiourea
• CAS No.: 118714-32-2
• Molecular Formula: C₁₂H₁₁F₃N₄S
• Molecular Weight: 300.307
• Mol file: 118714-32-2.mol

Synonyms:1-[4-(1H-Imidazol-4-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-thiourea

Chemical Property of 1-[4-(1H-Imidazol-4-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-thiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-(1H-Imidazol-4-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-thiourea

There total 3 articles about 1-[4-(1H-Imidazol-4-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,2,2-trifluroethylamine hydrochloride (373-88-6) + 4-(Imidazol-4-yl)-phenyl isothiocyanate (56337-96-3) → 1-[4-(1H-Imidazol-4-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-thiourea (118714-32-2)

Guidance literature:

With sodium methylate; 1) MeOH, 5 deg C, 5 min, 2) 5 deg C, 3 h;

DOI:10.1021/jm00125a006

Reference yield:

VUF 5801 (29528-28-7) → 1-[4-(1H-Imidazol-4-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-thiourea (118714-32-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) 30 percent methanolic NH₄OH / 1) MeOH, 0 deg C, 24 h, 2) 0 deg C, 15 min

2: NEt₃ / methanol

3: 90 percent / 4 percent NaOMe / methanol / 3 h / 5 °C

With ammonium hydroxide; sodium methylate; triethylamine; In methanol;

DOI:10.1021/jm00125a006

Reference yield:

Ethyl 4-(imidazol-4-yl)phenyldithiocarbamate (118714-29-7) → 1-[4-(1H-Imidazol-4-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-thiourea (118714-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NEt₃ / methanol

2: 90 percent / 4 percent NaOMe / methanol / 3 h / 5 °C

With sodium methylate; triethylamine; In methanol;

DOI:10.1021/jm00125a006

upstream raw materials:

2,2,2-trifluroethylamine hydrochloride

4-(Imidazol-4-yl)-phenyl isothiocyanate

VUF 5801

Ethyl 4-(imidazol-4-yl)phenyldithiocarbamate

Downstream raw materials:

N-[4-(1H-Imidazol-4-yl)-phenyl]-N'-(2,2,2-trifluoro-ethyl)-formamidine