8β-<(3,5-dioxo-4-phenylpiperazin-1-yl)methyl>-9,10-didehydro-6-methylergoline

Base Information

Chemical Name:8β-<(3,5-dioxo-4-phenylpiperazin-1-yl)methyl>-9,10-didehydro-6-methylergoline
CAS No.:131816-90-5
Molecular Formula:C₂₆H₂₆N₄O₂
Molecular Weight:426.518
Hs Code.:

Synonyms:8β-<(3,5-dioxo-4-phenylpiperazin-1-yl)methyl>-9,10-didehydro-6-methylergoline

Suppliers and Price of 8β-<(3,5-dioxo-4-phenylpiperazin-1-yl)methyl>-9,10-didehydro-6-methylergoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8β-<(3,5-dioxo-4-phenylpiperazin-1-yl)methyl>-9,10-didehydro-6-methylergoline

Chemical Property:

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Technology Process of 8β-<(3,5-dioxo-4-phenylpiperazin-1-yl)methyl>-9,10-didehydro-6-methylergoline

There total 6 articles about 8β-<(3,5-dioxo-4-phenylpiperazin-1-yl)methyl>-9,10-didehydro-6-methylergoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 136670-08-1
N-<(9,10-didehydro-6-methylergolin-8β-yl)methyl>-N-(phenylcarbamoylmethyl)-glycine

: 131816-90-5
8β-<(3,5-dioxo-4-phenylpiperazin-1-yl)methyl>-9,10-didehydro-6-methylergoline

Guidance literature:: With 1,1'-carbonyldiimidazole; In 1,4-dioxane; for 3h; Heating;
DOI:10.1016/S0223-5234(99)80045-2

Reference yield:

: 5878-41-1
lysergamine

: 131816-90-5
8β-<(3,5-dioxo-4-phenylpiperazin-1-yl)methyl>-9,10-didehydro-6-methylergoline

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / dimethylformamide / 3 h / Ambient temperature

2: 79 percent / KOH / ethanol / 3 h / Ambient temperature

3: 1) 1,1'-carbonyldiimidazole / 1) dioxane, reflux, 15 min, 2) dioxane, reflux, 3 h

4: 77 percent / KOH / ethanol / 3 h / 50 °C

5: 77 percent / 1,1'-carbonyldiimidazole / dioxane / 3 h / Heating

With potassium hydroxide; 1,1'-carbonyldiimidazole; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(99)80045-2

Reference yield:

: 62-53-3
aniline

: 131816-90-5
8β-<(3,5-dioxo-4-phenylpiperazin-1-yl)methyl>-9,10-didehydro-6-methylergoline

Guidance literature:: Multi-step reaction with 3 steps

1: 1) 1,1'-carbonyldiimidazole / 1) dioxane, reflux, 15 min, 2) dioxane, reflux, 3 h

2: 77 percent / KOH / ethanol / 3 h / 50 °C

3: 77 percent / 1,1'-carbonyldiimidazole / dioxane / 3 h / Heating

With potassium hydroxide; 1,1'-carbonyldiimidazole; In 1,4-dioxane; ethanol;
DOI:10.1016/S0223-5234(99)80045-2