[(3S,4S)-1-Benzyl-4-(5,5-difluoro-2-oxo-piperidin-1-yl)-pyrrolidin-3-yl]-carbamic acid methyl ester

Base Information

Chemical Name:[(3S,4S)-1-Benzyl-4-(5,5-difluoro-2-oxo-piperidin-1-yl)-pyrrolidin-3-yl]-carbamic acid methyl ester
CAS No.:1000303-24-1
Molecular Formula:C₁₈H₂₃F₂N₃O₃
Molecular Weight:367.396
Hs Code.:

Synonyms:[(3S,4S)-1-Benzyl-4-(5,5-difluoro-2-oxo-piperidin-1-yl)-pyrrolidin-3-yl]-carbamic acid methyl ester

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Chemical Property of [(3S,4S)-1-Benzyl-4-(5,5-difluoro-2-oxo-piperidin-1-yl)-pyrrolidin-3-yl]-carbamic acid methyl ester

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Technology Process of [(3S,4S)-1-Benzyl-4-(5,5-difluoro-2-oxo-piperidin-1-yl)-pyrrolidin-3-yl]-carbamic acid methyl ester

There total 12 articles about [(3S,4S)-1-Benzyl-4-(5,5-difluoro-2-oxo-piperidin-1-yl)-pyrrolidin-3-yl]-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1000303-23-0
[(3S,4S)-1-Benzyl-4-(5-chloro-4,4-difluoro-pentanoylamino)-pyrrolidin-3-yl]-carbamic acid methyl ester

: 1000303-24-1
[(3S,4S)-1-Benzyl-4-(5,5-difluoro-2-oxo-piperidin-1-yl)-pyrrolidin-3-yl]-carbamic acid methyl ester

Guidance literature:: With sodium t-butanolate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.5h;

Reference yield:

: 1000303-65-0
5-chloro-4,4-difluoropentanoic acid

: 1000303-24-1
[(3S,4S)-1-Benzyl-4-(5,5-difluoro-2-oxo-piperidin-1-yl)-pyrrolidin-3-yl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / ethyl acetate / Heating

2: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide

With sodium hydride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.055

Reference yield:

: 1000303-71-8
C₇H₁₁ClF₂O₂

: 1000303-24-1
[(3S,4S)-1-Benzyl-4-(5,5-difluoro-2-oxo-piperidin-1-yl)-pyrrolidin-3-yl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide

2: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / ethyl acetate / Heating

3: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide

With water; sodium hydride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; lithium hydroxide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.055