1-[4-(5-ethyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine

Base Information

Chemical Name:1-[4-(5-ethyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine
CAS No.:1439396-85-6
Molecular Formula:C₂₃H₂₃N₅
Molecular Weight:369.469
Hs Code.:

Synonyms:1-[4-(5-ethyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine

Suppliers and Price of 1-[4-(5-ethyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[4-(5-ethyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[4-(5-ethyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine

There total 7 articles about 1-[4-(5-ethyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {1-[4-(5-ethyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

: 1439396-85-6
1-[4-(5-ethyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1439394-87-2
tert-butyl 1-(4-(2-chloro-5-iodopyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

: 1439396-85-6
1-[4-(5-ethyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine

Guidance literature:: Multi-step reaction with 6 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.5 h / 80 °C / Inert atmosphere

2: caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

3: N-iodo-succinimide / dichloromethane / 20 °C / Inert atmosphere

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / propan-1-ol / 90 °C / Inert atmosphere

5: palladium on activated charcoal; hydrogen / methanol / Inert atmosphere; Reflux

6: hydrogenchloride / ethyl acetate / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; N-iodo-succinimide; copper(l) iodide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; caesium carbonate; triethylamine; In 1,4-dioxane; methanol; propan-1-ol; dichloromethane; ethyl acetate;

Reference yield:

: 1439394-88-3
tert-butyl 1-(4-(2-chloro-5-(pyridin-2-ylethynyl)pyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

: 1439396-85-6
1-[4-(5-ethyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

2: N-iodo-succinimide / dichloromethane / 20 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / propan-1-ol / 90 °C / Inert atmosphere

4: palladium on activated charcoal; hydrogen / methanol / Inert atmosphere; Reflux

5: hydrogenchloride / ethyl acetate / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; N-iodo-succinimide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; caesium carbonate; triethylamine; In 1,4-dioxane; methanol; propan-1-ol; dichloromethane; ethyl acetate;