ethyl 2-(2-iodo-5-methylbenzyl)-2-amino-3-(2-iodo-5-methylphenyl)propanoate

Base Information

• Chemical Name: ethyl 2-(2-iodo-5-methylbenzyl)-2-amino-3-(2-iodo-5-methylphenyl)propanoate
• CAS No.: 1394350-85-6
• Molecular Formula: C₂₀H₂₃I₂NO₂
• Molecular Weight: 563.217
• Mol file: 1394350-85-6.mol

Synonyms:ethyl 2-(2-iodo-5-methylbenzyl)-2-amino-3-(2-iodo-5-methylphenyl)propanoate

Chemical Property of ethyl 2-(2-iodo-5-methylbenzyl)-2-amino-3-(2-iodo-5-methylphenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(2-iodo-5-methylbenzyl)-2-amino-3-(2-iodo-5-methylphenyl)propanoate

There total 2 articles about ethyl 2-(2-iodo-5-methylbenzyl)-2-amino-3-(2-iodo-5-methylphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H21I2NO2 (1394351-55-3) → ethyl 2-(2-iodo-5-methylbenzyl)-2-amino-3-(2-iodo-5-methylphenyl)propanoate (1394350-85-6)

Guidance literature:

With hydrogenchloride; water; In ethanol; at 20 ℃;

DOI:10.1021/ja306631z

Reference yield:

2-(bromomethyl)-1-iodo-4-methylbenzene (1178576-91-4) → ethyl 2-(2-iodo-5-methylbenzyl)-2-amino-3-(2-iodo-5-methylphenyl)propanoate (1394350-85-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate / acetonitrile / 0 - 70 °C

2: water; hydrogenchloride / ethanol / 20 °C

With hydrogenchloride; water; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In ethanol; acetonitrile;

DOI:10.1021/ja306631z

Reference yield: 75.0%

ethyl 2-(2-iodo-5-methylbenzyl)-2-amino-3-(2-iodo-5-methylphenyl)propanoate (1394350-85-6) → (S)-ethyl 2-(2-iodo-5-methylbenzyl)-5-methylindoline-2-carboxylate (1394351-15-5)

Guidance literature:

With copper(l) iodide; (Ra)-3,3’-di(anthracen-9-yl)-[1,1’-binaphthalene]-2,2’-diol; caesium carbonate; In 1,4-dioxane; at 20 ℃; for 10h; enantioselective reaction;

DOI:10.1021/ja306631z

upstream raw materials:

2-(bromomethyl)-1-iodo-4-methylbenzene

C₂₁H₂₁I₂NO₂

Downstream raw materials:

(S)-ethyl 2-(2-iodo-5-methylbenzyl)-5-methylindoline-2-carboxylate