4-(5-chloro-2-methoxypyridin-4-ylamino)-7-(2, 4-dimethoxybenzyloxy) - 5-isopropoxyquinazoline

Base Information

Chemical Name:4-(5-chloro-2-methoxypyridin-4-ylamino)-7-(2, 4-dimethoxybenzyloxy) - 5-isopropoxyquinazoline
CAS No.:719304-92-4
Molecular Formula:C₂₆H₂₇ClN₄O₅
Molecular Weight:510.977
Hs Code.:

Synonyms:4-(5-chloro-2-methoxypyridin-4-ylamino)-7-(2, 4-dimethoxybenzyloxy) - 5-isopropoxyquinazoline

Suppliers and Price of 4-(5-chloro-2-methoxypyridin-4-ylamino)-7-(2, 4-dimethoxybenzyloxy) - 5-isopropoxyquinazoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(5-chloro-2-methoxypyridin-4-ylamino)-7-(2, 4-dimethoxybenzyloxy) - 5-isopropoxyquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(5-chloro-2-methoxypyridin-4-ylamino)-7-(2, 4-dimethoxybenzyloxy) - 5-isopropoxyquinazoline

There total 7 articles about 4-(5-chloro-2-methoxypyridin-4-ylamino)-7-(2, 4-dimethoxybenzyloxy) - 5-isopropoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 719305-30-3
5-chloro-2-methoxypyridin-4-amine

: 692059-53-3
4-chloro-7-(2, 4-dimethoxybenzyloxy)-5 isopropoxyquinazoline

: 719304-92-4
4-(5-chloro-2-methoxypyridin-4-ylamino)-7-(2, 4-dimethoxybenzyloxy) - 5-isopropoxyquinazoline

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2005.08.106

Reference yield:

: 719305-31-4
5-chloro-2-methoxypyridine-1-oxide

: 719304-92-4
4-(5-chloro-2-methoxypyridin-4-ylamino)-7-(2, 4-dimethoxybenzyloxy) - 5-isopropoxyquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: H₂SO₄; HNO₃ / 0 - 80 °C

1.2: Raney Ni / ethyl acetate; methanol

2.1: NaHMDS / tetrahydrofuran / 0 - 20 °C

With sulfuric acid; nitric acid; sodium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.08.106

Reference yield:

: 379228-58-7
5,7-difluoroquinazolin-4(3H)-one

: 719304-92-4
4-(5-chloro-2-methoxypyridin-4-ylamino)-7-(2, 4-dimethoxybenzyloxy) - 5-isopropoxyquinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / NaH / dimethylformamide / 5 - 20 °C

2: 68 percent / tBuOK / tetrahydrofuran / Heating

3: 62 percent / POCl₃; iPr₂NEt / 1,2-dichloro-ethane / 75 °C

4: NaHMDS / tetrahydrofuran / 0 - 20 °C

With potassium tert-butylate; sodium hexamethyldisilazane; sodium hydride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.08.106