(1S,3S,4R)-7-(benzyloxycarbonyl)-1-carboxy-3-[2-(N-(tert-butyloxycarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}amino)ethyl]-7-azabicyclo[2.2.1]heptane tert-butyl ester

Base Information

Chemical Name:(1S,3S,4R)-7-(benzyloxycarbonyl)-1-carboxy-3-[2-(N-(tert-butyloxycarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}amino)ethyl]-7-azabicyclo[2.2.1]heptane tert-butyl ester
CAS No.:182137-97-9
Molecular Formula:C₃₁H₅₀N₂O₈SSi
Molecular Weight:638.898
Hs Code.:

(1S,3S,4R)-7-(benzyloxycarbonyl)-1-carboxy-3-[2-(N-(tert-butyloxycarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}amino)ethyl]-7-azabicyclo[2.2.1]heptane tert-butyl ester

Synonyms:(1S,3S,4R)-7-(benzyloxycarbonyl)-1-carboxy-3-[2-(N-(tert-butyloxycarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}amino)ethyl]-7-azabicyclo[2.2.1]heptane tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,3S,4R)-7-(benzyloxycarbonyl)-1-carboxy-3-[2-(N-(tert-butyloxycarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}amino)ethyl]-7-azabicyclo[2.2.1]heptane tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1S,3S,4R)-7-(benzyloxycarbonyl)-1-carboxy-3-[2-(N-(tert-butyloxycarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}amino)ethyl]-7-azabicyclo[2.2.1]heptane tert-butyl ester

There total 5 articles about (1S,3S,4R)-7-(benzyloxycarbonyl)-1-carboxy-3-[2-(N-(tert-butyloxycarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}amino)ethyl]-7-azabicyclo[2.2.1]heptane tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 145387-82-2
N-(tert-butyloxycarbonyl)(2-trimethylsilylethyl)sulfonamide

: 182137-93-5
(1S,3S,4R)-3-(2-Hydroxy-ethyl)-7-aza-bicyclo[2.2.1]heptane-1,7-dicarboxylic acid 7-benzyl ester 1-tert-butyl ester

: 182137-97-9
(1S,3S,4R)-7-(benzyloxycarbonyl)-1-carboxy-3-[2-(N-(tert-butyloxycarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}amino)ethyl]-7-azabicyclo[2.2.1]heptane tert-butyl ester

Guidance literature:: With triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 4h;
DOI:10.1021/jo960759m

Reference yield:

: 182137-75-3
(1S,4R)-3-Oxo-7-aza-bicyclo[2.2.1]heptane-1,7-dicarboxylic acid 7-benzyl ester 1-tert-butyl ester

: 182137-97-9
(1S,3S,4R)-7-(benzyloxycarbonyl)-1-carboxy-3-[2-(N-(tert-butyloxycarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}amino)ethyl]-7-azabicyclo[2.2.1]heptane tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KHMDS / 1.) THF, room temperature, 15 min, 2.) THF, 4 deg C, 15 h; room temperature, 2 h.

2: H₂ / Pd/C / methanol / 12 h / 3102.9 Torr

3: 74 percent / LiBH₄ / diethyl ether / 4.5 h

4: 95 percent / Ph₃P / tetrahydrofuran / 4 h / 0 °C

With lithium borohydride; hydrogen; potassium hexamethylsilazane; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jo960759m

Reference yield:

: (1S,4R)-3-[1-Methoxycarbonyl-meth-(Z)-ylidene]-7-aza-bicyclo[2.2.1]heptane-1,7-dicarboxylic acid 7-benzyl ester 1-tert-butyl ester

: 182137-97-9
(1S,3S,4R)-7-(benzyloxycarbonyl)-1-carboxy-3-[2-(N-(tert-butyloxycarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}amino)ethyl]-7-azabicyclo[2.2.1]heptane tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol / 12 h / 3102.9 Torr

2: 74 percent / LiBH₄ / diethyl ether / 4.5 h

3: 95 percent / Ph₃P / tetrahydrofuran / 4 h / 0 °C

With lithium borohydride; hydrogen; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jo960759m